摘要
目的观察左西孟旦治疗慢性心力衰竭(CHF)的疗效。方法选取2014年9月~2015年9月在青岛阜外心血管病医院心脏中心住院治疗的CHF患者64例,其中男性35例,女性29例,年龄39~79(58.76±12.89)岁,将所有患者随机分为观察组与对照组,每组各32例。对照组给予传统抗心力衰竭治疗,观察组在对照组基础上加用左西孟旦注射液治疗。于治疗前后检测左室射血分数(LVEF)、N末端脑钠肽前体(NT-pro BNP)和评价治疗的疗效。结果对照组显效11例(34.4%),有效11例(34.4%),总有效率68.8%;观察组显效12例(37.6%),有效15例(46.8%),总有效率84.4%,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,观察组和对照组LVEF升高,NT-pro BNP降低,差异有统计学意义(P均<0.05)。与对照组治疗后比较,观察组LVEF[(36.31±7.39)%vs.(39.87±6.74)%]升高,NT-pro BNP[(5904.23±1027.35)pg/ml vs.(5418.06±1008.40)pg/ml]降低,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论加用左西孟旦治疗较传统治疗有效,能显著改善CHF患者的心功能和心肌损伤。
Objective To observe the curative effect of levosimendan on chronic heart failure (CHF). Methods CHF patients (n=64, male 35, female 29, aged from 39 to 79 and average age=58.76 ±12.89) were chosen from Sept. 2014 to Sept. 2015, and then randomly divided into observation group and controi group (each n=32). The control group was given traditional anti-CHF therapy, and observation group was additionally given levosimendan injection. The changes of left ventricular ejection fraction (LVEF) and N-terminal pro brain natriuretic peptide (NT-proBNP) were detected before and after treatment, and curative effect of levosimendan was reviewed. Results There were 11 eases (34.4%) with significant curative effect and 11 (34.4%) with curative effect, and the total effective rate was 68.8% in control group. There were 12 cases (37.6%) with significant curative effect and 15 (46.8%) with curative eft^ct, and the total effective rate was 84.4% in observation group. The difference was significant statistically between 2 groups (P〈0.05). The level of LVEF increased and level of NT-proBNP decreased in 2 groups after treatment (all P〈0.05). Compared with control group, LVEF [(36.31 ± 7.39)% vs. (39.87 ± 6.74)%] increased and NT-proBNP [(5904.23 ± 1027.35) pg/ml vs. (5418.06± 1008.40) pg/ml] decreased in observation group after treatment (all P〈0.05). The difference in incidence of adverse reactions had no statistical significance between 2 groups (P〉0.05). Conclusion Levosimendan combining traditional therapy has higher curative effect than only traditional therapy, which can significantly improve heart function and relieve myocardial injury in CHF patients.
出处
《中国循证心血管医学杂志》
2016年第3期342-344,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
慢性心力衰竭
左西孟旦
左室射血分数
NT-pro
BNP
Chronic heart failure
Levosimendan
Left ventricular ejection fraction
N-terminal pro brainnatriurelic peptide