急性心肌梗死患者血清GDF-15与CK-MB、cTnI、Mb之间的关系

Relationship among serum growth differentiation factor-15, creatine kinase MB, cardiac troponin I and myoglobin in patients with acute myocardial infarction

目的 探讨急性心肌梗死（AMI）患者血清生长分化因子-15（GDF-15）与肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（c Tn I）、肌红蛋白（Mb）之间的关系。方法 选取广东省台山市人民医院心内科2013年12月~2014年12月收治的AMI患者127例即观察组,其中男性71例,女性56例,年龄51~82岁,平均年龄（71.28±10.83）岁;同时选取在本院体检的健康人群104例作为对照组,其中男性62例,女性42例,年龄50~84岁,平均年龄（70.02±11.76）岁。检测两组血清转化生长因子15（GDF-15）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（c Tn I）、肌红蛋白（Mb）水平。结果 观察组血清GDF-15水平明显高于对照组[（3.04±1.09）g/L vs.（0.41±0.13）g/L],差异有统计学意义（P〈0.01）。与对照组比较,观察组c Tn I、CK-MB和Mb均升高,数值为[（0.31±0.11）g/L vs.（3.82±1.53）g/L]、[（16.53±5.09）g/L vs.（45.07±13.16）g/L]和[（40.17±4.15）g/L vs.（201.11±45.62）g/L],差异有统计学意义（P均〈0.05）。Pearson相关分析结果显示,血清GDF-15与c Tn I、CK-MB、Mb呈正相关,相关系数分别为0.427、0.409、0.511（P均〈0.01）。结论 急性心肌梗死患者GDF-15与c Tn I、CK-MB和Mb均升高,且GDF-15越高c Tn I、CK-MB和Mb也越高,GDF-15可能成为AMI诊断的新指标。

Objective To discuss the relationship among serum growth differentiation factor-15 （GDF-15）, ereatine kinase MB （CK-MB）, cardiac troponin I （eTnI） and myoglobin （Mb） in patients with acute myocardial infarction （AMI）. Methods AMI patients （n=127, male 71, female 56, aged from 51 to 82 and average age=71.28 ± 10.83） were chosen as observation group from Dec. 2013 to Dec. 2014. Meanwhile the healthy controls with physical examinations （n=104, male 62, female 42, aged from 50 to 84 and average age=70.02 ± 11.76） were chosen as control group. The levels of serum GDF-15, CK-MB, cTnI and were detected in 2 groups. Results The level of serum GDF-15 was significantly higher in observation group than that in control group [（3.04± 1.09） g/L vs. （0.41 ± 0.13） g/L, P〈0.01]. Compared with control group, the levels of cTnI, CK-MB and Mb increased [（0.31 ± 0.11） g/Lvs. （3.82± 1.53） g/L], [（16.53 ± 5.09） g/L vs. （45.07±13.16） g/L] and [（40.17±4.15） g/L vs. （201.11±45.62） g/L] in observation group （all P〈0.05）. The results of Pearson correlation analysis showed that level of serum GDF-15 was positively correlated to eTnI, CK-MB and Mb （r=0.427, r=0.409, r=0.511, all P〈0.05）. Conclusion The levels of serum GDF-15, eTnI, CK-MB and Mb all increase in AMI patients, and GDF-15 is positively correlated to eTnI, CK-MB and Mb. GDF-15 may be a new diagnostic index for AMI.