体质量指数与食管贲门腺癌发病风险相关性Meta分析

Meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma

目的分析不同体质量指数（BMI）与食管贲门腺癌发病风险相关性。方法通过Medline、Pub Med、Embase、WOS检索至2015年相关文献,统计分析BMI与食管、贲门腺癌的发病关系。结果 22项研究入选病例数共1 307 549例,其中试验组7 718例,对照组1 299 831例。BMI 25-30 kg/m2,贲门、食管腺癌发病总风险RR=1.56,95%CI：1.46-1.68（P=0.000）;食管腺癌RR=1.82,95%CI：1.57-2.11（P=0.00）;贲门腺癌RR=3.47,95%CI：1.93-6.25（P=0.000）;贲门、食管同时癌变RR=1.47,95%CI：1.35-1.59（P=0.000）。BMI≥30 kg/m2,贲门、食管腺癌发病相对风险RR=2.19,95%CI：1.96-2.45（P=0.000）;贲门及食管同时发生癌变相对风险RR=2.11,95%CI：1.86-2.39（P=0.000）;贲门腺癌发生风险RR=2.58,95%CI：1.24-5.35（P=0.011）;食管腺癌发生风险RR=2.49,95%CI：1.95-3.17（P=0.000）。结论 BMI〉25 kg/m2时,贲门、食管腺癌发病率明显升高。

Objective To evaluate the relationship of body mass index（BMI） with esophageal and gastric cardia adenocarcinoma. Methods Related articls（1990- 2015） were searched in Medline,Pub Med,Embase,WOS. The qualities of the included studies were evaluated by the Jadad scale. RR and 95% CI were evaluated by Meta-analysis.Results A total of 22 studies were adopted,and the number of cases was 1 307 549,experimental group had 7 718 cases,control group had 1 299 831 cases. The Meta-analysis showed that： when BMI was 25-30 kg / m2,esophageal or gastric cardia adenocarcinoma RR was 1. 56（95% CI： 1. 46-1. 68,P = 0. 000）; esophageal adenocarcinoma RR was 1.82（95% CI： 1. 57-2. 11,P = 0. 00）; gastric cardia adenocarcinoma RR was 3. 47（95% CI： 1. 93-6. 25,P = 0. 000）;esophageal and gastric cardia adenocarcinoma RR was 1. 47（95% CI： 1. 35-1. 59,P = 0. 000）. BMI was more than 30 kg / m2,esophageal or gastric cardia adenocarcinoma RR was 2. 19（95% CI： 1. 96-2. 45,P = 0. 000）; esophageal and gastric cardia adenocarcinoma RR was 2. 11（95% CI： 1. 86-2. 39,P = 0. 000）; gastric cardia adenocarcinoma RR was2. 58（95% CI： 1. 24-5. 35,P = 0. 011）; esophageal adenocarcinoma RR was 2. 49（95% CI： 1. 95-3. 17,P = 0. 000）.Conclusion The morbidity of esophageal and gastric cardia adenocarcinoma is high when BMI is more than 25 kg / m2.