摘要
目的系统评价氟哌噻吨美利曲辛辅助治疗中国溃疡性结肠炎(ulcerative colitis,UC)患者的临床疗效。方法通过中国知网、万方数据库、重庆维普数据库、百度学术、Pub Med及Cochrane Library检索关于对比氟哌噻吨美利曲辛联合传统药物(观察组)与单用传统药物(对照组)治疗UC疗效的随机对照试验,根据文献纳入标准筛选文献,采用Jadad量表对纳入的文献进行质量评价,应用Cochrane协作网提供的Revman 5.2软件进行Meta分析。结果共有9项随机对照试验纳入研究,共计498例患者,异质性检验I2=0(χ2=1.56,P=0.99),固定效应模型分析其合并比值比OR=4.61(95%CI:2.74-7.77),统计检验Z=5.75(P〈0.05)。结论氟哌噻吨美利曲辛联合传统药物治疗UC的疗效优于单用传统药物。
Objective To systematically evaluate the clinical effect of Flupentixol and melitracen as adjunctive therapy on Chinese patients with ulcerative colitis( UC). Methods Studies on Flupentixol and melitracen combined with traditional drugs and traditional drugs alone in the treatment of UC were collected and reviewed through searching CNKI,Wan Fang database,Chongqing VIP database,Baidu academic,Pub Med and Cochrane Library. The relevant literature was collected based on the inclusion criteria,and the methodological quality of the included trials was assessed by Jadad scale. Meta-analysis was performed by Revman 5. 2 software applied by Cochrane network. Results Nine randomized controlled trials were included involving 498 patients. The result of heterogeneity test showed that I2 was 0( χ2= 1. 56,P = 0. 99). For the fixed-effect model,the odds ratio was 4. 61(95% CI: 2. 74- 7. 77). Statistical test Z was 5. 75(P〈0 05). Conclusion Therapeutic effect of Flupentixol and melitracen combined with traditional drugs in the treatment of UC is better than single use of traditional drugs.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第4期457-460,共4页
Chinese Journal of Gastroenterology and Hepatology