脑源性神经营养因子表达与双相障碍双相躁狂和双相抑郁的关系研究

Research on relationship between expression of brain derived neurotroph ic factor and bipolar disorder

目的探究双相躁狂、双相抑郁与脑源性神经营养因子表达关系。方法将60例双相障碍患者作为研究对象,据躁狂量表与汉密尔顿抑郁量表分为研究组与观察组,同期选30名健康者为对照组。观察双相障碍患者脑源性神经营养因子表达的关系。结果研究组、观察组与对照组3组脑源性神经营养因子比较,对照组高于研究组与观察组,差异有统计学意义(P<0.05);研究组、观察组与对照组3组白细胞介素-1β血清水平比较,对照组明显高于研究组与观察组,差异有统计学意义(P<0.05)。结论双相障碍患者脑源性神经营养因子低表达均明显较低。

Objective To explore the relationship between the expression of brain-derived neurotrophic factor and manic bipolar,bipolar depression. Methods Sixty patients with bipolar disorder patients were as research subjects,according to Mania Rating Scale and the Hamilton Depression Scale divided into study group and the observation group,30 cases of the same period of healthy were as control group. Observation of patients with bipolar disorder brain-derived neurotrophic factor expression. Results The brain-derived neurotrophic factor of was decreased than study group and control group the control group（P〈0.05）;Serum levels of IL-1β of the control group was significantly higher than the study and observation group（P〈0.05）. Conclusion Bipolar disorder brain-derived neurotrophic factor expression were significantly lower low.