创伤性脑损伤后认知障碍的MRI研究进展

A review of the application of MRI techniques in cognitive impairment after traumatic brain injury

创伤性脑损伤(traumatic brain injury,TBI)后可有一系列并发症发生,认知障碍是最常见、最持久的并发症之一。目前关于TBI后认知障碍的临床诊断大多停留在应用神经心理学的方法,缺乏认知障碍发生的客观结构改变证据,从而影响了TBI后认知障碍的早期诊断、治疗方案确定及预后评价。近年来,随着影像技术尤其是磁共振成像(magnetic resonance imaging,MRI)新序列的研发,多种新兴、无创MRI新序列可以清晰显示全脑的微细结构并可构建出脑网络结构。笔者通过阅读大量文献总结了各种MRI新技术在评价TBI后认知障碍发生的研究进展。

Traumatic brain injury（TBI） is closely related to a series of complications,among which cognitive impairment is a most common and long-lasting one. Currently,the diagnosis of cognitive impairment after TBI remained mostly by using a neuropsychological method while lacking the evidence of objective brain structure changes, thus affecting the treatment plan and prognosis assessment. In recent years,with the development of new MRI sequence imaging technology, a variety of new MRI sequences can clearly show the micro-structure of the whole brain and brain network. In this review, we mainly summarize the research progress of new MRI sequence in evaluation of cognitive impairment after TBI.