期刊文献+

非编码RNA(ncRNA)在前列腺癌发生发展中的作用机制 被引量:1

Research Progress of Non-coding RNA(ncRNA) Mechanism in Prostate Cancer
原文传递
导出
摘要 人类基因组计划的研究结果显示,仅有2.5万~3万个蛋白质编码基因,占总基因组序列不到3%,其余基因组序列转录产生的RNA都是非编码RNA(non-coding RNA,ncRNA).ncRNA与恶性肿瘤发生发展关系密切.近年来,关于ncRNA中的长链非编码RNA(lncRNA)以及环状RNA(circRNA)的研究进展迅速.本文就lncRNA以及circRNA在前列腺癌中作用机制的研究进展作一综述. Completion of the Human Genome Project revealed that less than 3% of the human genome encodes for proteins. RNAs transcribed by the majority of the genome are non-coding RNAs(ncRNAs). ncRNAs are closely related to malignant tumor development. Studies of long-ncRNAs(lncRNAs) and circular RNAs(circRNAs) have progressed rapidly in recent years. In this paper, the mechanism and function of lncRNA and circRNA in prostate cancer is summarized.
出处 《中国科学:生命科学》 CSCD 北大核心 2016年第4期385-391,共7页 Scientia Sinica(Vitae)
基金 国家自然科学基金(批准号:31571330) 上海市科学技术委员会基地项目(批准号:13DZ2252000)资助
关键词 lncRNA 前列腺癌 AR circRNA lncRNA prostate cancer AR circRNA
  • 相关文献

参考文献66

  • 1Holt J E, Stanger S J, Nixon B, et al. Non-coding RNA in spermatogenesis and epididymal maturation. Adv Exp Med Biol, 2016, 886: 95-120.
  • 2Teng K Y, Ghoshal K. Role of noncoding RNAs as biomarker and therapeutic targets for liver fibrosis. Gene Expr, 2015, 16:155-162.
  • 3Sugihara H, Ishimoto T, Miyake K, et al. Noncoding RNA expression aberration is associated with cancer progression and is a potential biomarker in esophageal squamous cell carcinoma. Int J Mol Sci, 2015, 16:27824-27834.
  • 4Setoyama T, Ling H, Natsugoe S, et al. Non-coding RNAs for medical practice in oncology. Keio J Med, 2011, 60:106-113.
  • 5Kogo R, Shimamura T, Mimori K, et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res, 2011, 71:6320-6326.
  • 6Vrba L, Garbe J C, Stampfer M R, et al. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers. Epigenetics, 2015, 10:1074-1083.
  • 7Li J, Yang J, Zhou P, et al. Circular RNAs in cancer: novel insights into origins, properties, functions and implications. Am J Cancer Res 2015, 5:472-480.
  • 8Tsai M C, Manor O, Wan Y, et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science, 2010, 329 689-693.
  • 9Gupta R A, Shah N, Wang K C, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
  • 10Kornienko A E, Guenzl P M, Barlow D P, et al. Gene regulation by the act of long non-coding RNA transcription. BMC Biol, 2013, 11: 59.

同被引文献4

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部