摘要
人类基因组计划的研究结果显示,仅有2.5万~3万个蛋白质编码基因,占总基因组序列不到3%,其余基因组序列转录产生的RNA都是非编码RNA(non-coding RNA,ncRNA).ncRNA与恶性肿瘤发生发展关系密切.近年来,关于ncRNA中的长链非编码RNA(lncRNA)以及环状RNA(circRNA)的研究进展迅速.本文就lncRNA以及circRNA在前列腺癌中作用机制的研究进展作一综述.
Completion of the Human Genome Project revealed that less than 3% of the human genome encodes for proteins. RNAs transcribed by the majority of the genome are non-coding RNAs(ncRNAs). ncRNAs are closely related to malignant tumor development. Studies of long-ncRNAs(lncRNAs) and circular RNAs(circRNAs) have progressed rapidly in recent years. In this paper, the mechanism and function of lncRNA and circRNA in prostate cancer is summarized.
出处
《中国科学:生命科学》
CSCD
北大核心
2016年第4期385-391,共7页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:31571330)
上海市科学技术委员会基地项目(批准号:13DZ2252000)资助