乌司他丁对重症肺炎患者肺表面活性蛋白及抗炎、促炎介质的影响

Influence of ulinastatin on pulmonary surfactant protein,anti-inflammatory and pro-inflammatory mediators in treatment of patients with severe pneumonia

目的观察乌司他丁对重症肺炎患者肺表面活性蛋白及抗炎、促炎介质的影响。方法选取54例重症肺炎患者随机分为对照组(常规重症肺炎治疗组)27例和观察组(常规治疗加乌司他丁组)27例,然后将2组治疗前与治疗后1 d、3 d及5 d时的血清肺表面活性蛋白及抗炎、促炎介质水平进行比较。结果治疗前2组患者的血清肺表面活性蛋白及抗炎、促炎介质水平均差异无统计学意义,而治疗后1d、3d及5d观察组的血清肺表面活性蛋白及抗炎、促炎介质水平均优于对照组(均P<0.05)。结论乌司他丁可有效改善重症肺炎患者的肺表面活性蛋白及抗炎、促炎介质,对于重症肺炎的各方面改善作用明显。

Objective To study the influence of ulinastatin on pulmonary surfactant protein and anti-inflammatory and pro-inflammatory mediators of patients with severe pneumonia. Methods 54 patients with severe pneumonia were randomly divided into control group（ conventional treatment of severe pneumonia group） 27 cases and observation group（ conventional treatment and ulinastatin group） 27 cases,then the serum pulmonary surfactant protein,anti-inflammatory and pro-inflammatory mediators of two groups before the treatment and at first,third and fifth day after the treatment were compared. Results The serum pulmonary surfactant protein,anti-inflammatory and pro-inflammatory mediators of two groups before the treatment had no significant differences,and those serum indexes of observation group at first,third and fifth day after the treatment were all better than those of control group（ all P〈0. 05）. Conclusion Ulinastatin can effectively improve the pulmonary surfactant protein,anti-inflammatory and pro-inflammatory mediators of patients with severe pneumonia,and its improvement role for various of severe pneumonia are obvious.