替考拉宁在粒细胞减少血液病感染中的应用价值

Application value of teicoplanin in granulocytopenia of hematopathy with infection

目的探讨替考拉宁在粒细胞减少血液病感染中的应用价值。方法选取2013年3月~2015年12月绍兴市中心医院血液风湿科收治的94例粒细胞减少血液病感染患者分为2组,每组47例。对照组采用头孢地嗪联合左氧氟沙星治疗,观察组在对照组治疗基础上采用替考拉宁治疗。治疗7d后,对比2组临床症状改善及不良反应发生情况。结果观察组总有效率显著高于对照组（80.85%vs.63.83%,χ^2=4.414,P〈0.05）。观察组体温恢复正常时间、平均住院时间显著低于对照组（t=6.244、3.734,P〈0.05）,病原菌清除率显著高于对照组（85.11%vs.65.96%,χ^2=4.663,P〈0.05）。2组不良反应发生率对比差异无统计学意义（12.77%vs.10.64%,χ^2=0.103,P〉0.05）。结论替考拉宁治疗粒细胞减少血液病感染的疗效确切,能显著改善患者临床症状,提高病原菌清除率,且安全性高。

Objective To explore the application value of teicoplanin in granulocytopenia of hematopathy with infection. Methods 94 cases of hematopathy with infection from March 2013 to December 2015 in our hospital were divided into two groups,47 cases in each group. The control group received cefixime combined with norfloxacin treatment. The observation group received teicoplanin on the basis of control group with consecutive treatment of 7 days. The improvement of clinical symptoms and adverse reactions were compared between two groups. Results The total effective rate of observation group was significantly higher than that of control group（ 80. 85% vs. 63. 83%,χ~2= 4. 414,P〈0. 05）. The temperature recovery time and average hospital stay of observation group were significantly lower than control group（ t = 6. 244,3. 734,P〈0. 05）. The clearance rate of pathogenic bacteria of observation group was significantly higher than that of control group. There were no significant difference in adverse reactions between two groups（ 12. 77% vs. 10. 64%,χ~2= 0. 103,P〉0. 05）. Conclusion Teicoplanin has an exact efficacy in the treatment of granulocytopenia of hematopathy with infection,could significantly improve the clinical symptoms and the clearance rate of pathogens with high safety.