甲硝唑、制霉菌素联合应用对滴虫性阴道炎患者血清炎性因子水平的影响

Effect of metronidazole combined with nystatin on serum inflammatory factors in patients with trichomonas vaginitis

目的探究甲硝唑、制霉菌素联合应用对滴虫性阴道炎患者血清炎性因子水平影响。方法收集湖北省武汉市普爱医院妇科收治的滴虫性阴道炎患者74例,根据随机对照表分为对照组和试验组,每组各37例。对照组给予臭氧妇科治疗仪治疗,甲硝唑片0.4 mg口服,2次/天,试验组在对照组的基础上联合应用制霉菌素,制霉菌素片研成粉剂0.4 mg置入患者阴道后穹窿处,2次/天,2组患者共治疗7 d。治疗结束后对比分析2组临床疗效、血清白介素-2(IL-2)、白介素-8(IL-8)、白介素-13(IL-13)水平以及不良反应。结果治疗后2组血清IL-2、IL-8以及IL-13水平下降(P<0.05),与对照组相比,试验组血清IL-2、IL-8以及IL-13水平较低(P<0.05)。2组不良反应比较,差异无统计学意义。结论甲硝唑、制霉菌素联合应用对滴虫性阴道炎患者的临床疗效显著,有效降低血清IL-2、IL-8以及IL-13水平,药物安全性高。

Objective To explore effect of metronidazole combined with nystatin on serum inflammatory factors in patients with trichomonas vaginitis. Methods A total of 74 cases with trichomonal vaginitis were randomly divided into experimental group and control group,37 cases in each group. Control group was treated with ozone gynecological therapeutic apparatus,metronidazole 0. 4 mg,2 times per day orally,experimental group were treated on the basis of control group combined application of nystatin,nystatin prime piece of grind into powder 0. 4 mg implantation with posterior vaginal fornix,2 times per day,patients were treated for 7days. The clinical efficacy of serum interleukin-2,interleukin-8 and interleukin-13 levels and adverse reactions were compared after the treatment. Results After treatment,IL-2,IL-8 and IL-13 level decreased in serum in two groups（ P〈0. 05）,compared with control group post-treatment,the serum IL-2,IL-8 and IL-13 levels were lower（ P〈0. 05）. There was no statistically significant difference in adverse reactions of two groups. Conclusion Metronidazole combined with nystatin in the treatment of trichomonas vaginitis have a curative clinical effect,reduce the serum IL-2,IL-8 and IL-13 levels and high safety.