骨骼肌发育调控相关lncRNAs研究进展

Research Progress of Long Noncoding RNAs in the Regulation of Skeletal Muscle Development

长链非编码RNA(Long non-coding RNA,lncRNA)是一类长度大于200个核苷酸、无蛋白质编码功能的RNA。相对于研究较多的短链非编码RNA,lncRNA的种类繁多,数量占哺乳动物基因组的绝大部分,功能目前尚不完全清楚。近年来研究发现,lncRNA的功能涉及表观遗传、转录调控、细胞分化、胚胎发育以及疾病发生等诸多方面。本文总结了lncRNA的分类、作用机制及其在骨骼肌发育调控和家养动物中的研究进展。

Long non-coding RNAs（lncRNAs）are a novel class of RNAs,which are longer than 200 nucleotides and have no protein-coding potential.In comparison with short noncoding RNAs which was studied extensively,a variety of long noncoding RNAs account for the majority of the transcripts in mammalian genome and the functions of lncRNAs are little understood.The recent studies have indicated that lncRNAs＇ function involved in epigenetic modification,transcriptional regulation,cell differentiation,embryonic development and disease occurrence.In this review,we summarized the classification and molecular mechanisms of lncRNA,and research advances in the regulation of skeletal muscle development and domestic animal.