精神分裂症患者顶下小叶亚区水平灰质体积损害分析

Subregional-level grey matter volume impairments in the inferior parietal lobule in schizophrenia

目的:探讨精神分裂症患者顶下小叶(IPL)亚区水平灰质体积(GMV)损害及其与临床症状的关系。方法:收集95例精神分裂症患者和104例性别和年龄匹配的正常人的MRI结构像。依据前人的分割结果,将IPL分为11个亚区,计算每个被试各亚区的GMV。利用一般线性模型在控制年龄和性别条件下对其进行组间比较,并计算存在显著统计学差异的亚区GMV与临床症状评分的相关性。结果:精神分裂症患者双侧IPL所有5个前部亚区的GMV均存在显著性减低;中后部6个亚区中只有1个亚区GMV减低。左侧PFt区的GMV与病程呈负相关(r=-0.212,P=0.042),而右侧PF+PFt区的GMV与PANSS阳性症状评分呈正相关(r=0.231,P=0.027)。结论:精神分裂症患者顶下小叶结构损害以前部亚区为主。

Objective： To explore subregional-level grey matter volume（GMV） impairments in the inferior parietal lobule（IPL） in schizophrenia and their clinical correlations. Methods： MRI structural images were obtained from 95 schizophrenia patients and 104 sex- and age-matched healthy subjects. Based on a previous parcellation study, the IPL was divided into 11 subregions. The GMV of each subregion was calculated for each subject and was compared between the two groups using general linear model after controlling for the effects of sex and age. Spearman＇s correlation coefficients were calculated between the GMVs of the IPL subregions with significant intergroup differences and the clinical parameters. Results： Compared with healthy subjects, schizophrenia patients showed significant GMV reduction in all the 5 anterior subregions and in only 1 middle and posterior subregion of the IPL. The GMV of the left PFt showed negative correlation with the duration of the illness（r=-0.212, P=0.042） and the GMV of the right PF＋PFt was positively correlated with the PANSS positive score（r=0.231, P=0.027）. Conclusion： The anterior subregions are the main portion of the IPL that exhibits structural impairments in schizophrenia.