盐酸舍曲林片治疗溃疡性结肠炎合并抑郁症的疗效观察

Curative effect of sertraline hydrochloride tablets on depression in patients with ulcerative colitis

目的了解盐酸舍曲林片治疗溃疡性结肠炎合并抑郁症的疗效，为该疾病提供有效的药物干预措施。方法74例溃疡性结肠炎并抑郁症患者被随机分为观察组42例和对照组32例，除支持治疗和心理干预之外，观察组被给予舍曲林联合美沙拉嗪，对照组被给予美沙拉嗪。评价2组的溃疡性结肠炎活动指数（UCAI）、抑郁自评量表（SDS）、汉密顿抑郁量表（HAMD）评分。结果2组治疗后的UCAI、S1）S、HAMD量表评分与治疗前相比均下降，差异有统计学意义（t=8．074、8．679、13．269、6．906、3．321、7．604，P均〈0．05）；2组治疗后的UCAI差异无统计学意义（t=0．972，P〉0．05）；治疗后观察组的SDS、HAMD量表评分均低于对照组（t=3．958、2．945，P均〈0．05）。治疗后，观察组的溃疡性结肠炎的总有效率为71．43％（30／42），对照组总有效率为65．63％（21／32），差异无统计学意义（χ^2=0．286，P〉0．05）。治疗后，观察组的抑郁症的总有效率为78．57％（33／42），高于对照组的53．13％（17／32）（χ^2=5．367，P〈0．05）。治疗过程中，观察组的药物不良反应发生率为19．05％（8／42）；对照组的不良反应发生率为21．88％（7／32）；差异无统计学意义（χ^2=0．090，P〉0．05）。结论舍曲林可在美沙拉嗪治疗溃疡性结肠炎的同时，发挥良好的治疗抑郁症的作用，并未增加约物小良反应发生率。

Objective To investigatethe curative effect of sertraline hydrochloride tablets in the treatment of depression in patients with ulcerative colitis and provide an effective drug intervention for depression. Methods Total 74 patients with ulcerative colitis complicated with depression were randomly divided intoobservation group （42 cases ） and control group （32 cases）. In addition to support treatment and psychological intervention, the observe group received also sertraline combined and mesalazine ,while the control group received only mesalazine. Ulcer colitis activity index （UCAI）, depression self-rating scale （SDS） and Hamilton Depression Rating Scale （HAMD） of both groups was evaluated. Results After thetreatment,UCAI, SDS and HAMD scale scores in both groups were decreased as compared with the values before treatment, the difterences were statistically significant （ t = 8. 074,8. 679,13. 269,6. 906,3.321,7. 604, P 〈 0.05 ） ; There was no significant difference in UCAI between the two groups after the treatment （ t = 0. 972, P 〉 0.05 ）. After the treatment, SDS and HAMD scale scores of the observation group were lower than those in the control group（t =3. 958,2. 945 ,P 〈 0.05 ）. After the treatment, the total effective rate for ulcerative colitis in the observation group was 71.43% （30/42） , and in the control group was 65.63 % （21/32）, the difference was not statistically significant （ χ^2 = 0. 286, P 〉 0.05 ）. After the treatment, the total effective rate of depression of the observation group was 78.57% （33/42）, and the total effective rate of the control group was 53.13 % （17/32） , χ^2= 5. 367, P 〈 0.05. During the treatment, the adverse drug reaction rate of the observation group was 19.05 % （8/42） and in the control group was 21.88% （7/32）, there was no statistically sig- nificant difference （ χ^2 = 0. 090, P 〉 0.05 ）. Conclusion Among the patients receiving mesalazine for ulcer colitis, the administration of sertraline can play good role in the treatment of depression, without increase in the incidence of adverse drug reactions.