齐墩果酸A环与C环内酯衍生物的设计合成

Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives

齐墩果酸是一个五环三萜类天然产物,具有多种生物活性和药理活性.以齐墩果酸为起始原料,采用间氯过氧苯甲酸以及过氧化脲等试剂进行其A环和C环内酯化修饰,以较高收率获得了系列齐墩果酸A/C环内酯化衍生物.所有产物均经~1H NMR、^(13)C NMR和高分辨质谱数据分析进行了结构确定,其中有12个化合物为新化合物.

Oleanolic acid（OA）, a naturally occurring triterpene, was found to have a variety of biological and pharmacological properties. To expand its structural diversity, a series of oleanolic acid derivatives, including ring A and/or ring C expansion, were performed via Baeyer-Villiger reaction using m-CPBA and urea-hydrogen peroxide. The structures of all products were characterized by ~1H NMR, ^（13）C NMR and HRMS.