哌啶乙酸盐催化合成2,3-二取代-苯并二氢吡喃-4-酮和2,2-二取代-苯并呋喃-3-酮类衍生物

Piperidinium Acetate-Catalyzed the Synthisis of 2,3-Disubstituted Chroman-4-one and 2,2-Disubstituted Benzofuran-3-one Derivatives

发展了一种以哌啶乙酸盐为催化剂,催化邻羟基苯基β-二酮和不同系列醛进行Knoevenagel与O-Micheal串联反应的新方法,以较好的底物适应性及中等以上的产率,合成了16个2,3-二取代苯并二氢吡喃-4-酮和9个2,2-二取代苯并呋喃-3-酮类衍生物,并且该串联反应合成途径简捷,反应条件温和,催化剂廉价易得.

A piperidinium acetate-catalyzed method was developed for the Knoevenagel and O-Micheal cascade reaction of o-hydroxyphenyl-β-diketoes with different series of aldehydes. In the presence of piperidinium acetate, sixteen 2,3-disubstituted chroman-4-ones and nine 2,2-disubstituted benzofuran-3-ones were obtained in moderate to good yields, and the cascade reaction displayed better substrate adaptability. Moreover, the reaction has the following features： a convenient and simple path, mild reaction conditions and a cheap catalyst.