一种构建吡喃并[2,3-d]嘧啶酮衍生物的简易方法

A Convenient Method to Prepare Pyrano[2,3-d]pyrimidine Derivatives

在浓硫酸催化下,2-氨基-3-氰基-4H-吡喃类化合物与乙酸酐反应,较高产率地合成了一系列吡喃并[2,3-d]嘧啶酮衍生物.该方法反应时间短（10~15 min）、操作简单、后处理方便.所合成产物的结构经红外光谱、核磁共振谱表征确证,其中化合物4a和6a的结构还通过X射线单晶衍射分析确认.

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized by the reaction of 2-amino-3-cyano-4H-pyrans with acetic anhydride. This method has the advantages of short reaction times（10~15 min）, simple operation and convenient post-treatment. All products were fully characterized by IR and 1H NMR spectra. The molecular structures of 4a and 6a were confirmed using single-crystal X-ray analyses.