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Ph-like急性淋巴细胞白血病

Ph-like acute lymphoblastic leukemia
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摘要 Ph-like急性淋巴细胞白血病(ALL)是具有和Ph+ALL相似的基因表达谱以及相似的临床预后的一组白血病。基因组学研究发现Ph-like ALL与细胞因子受体基因、酪氨酸激酶以及RAS家族基因的突变相关。针对这些信号通路的激酶抑制剂治疗已经使部分相应的患者获得了更好的疗效。 Ph-like acute lymphoblastic leukemia（ALL）is a recently defined subgroup of leukemia with gene expression profile and prognosis similar to Ph chromosome positive ALL.Genomics study has revealed Ph-like ALL is associated with mutations happening to cytokine receptor,tyrosine kinases and Ras family. Kinase inhibitors targeting the mutated molecules have already benefited several patients with Ph-like ALL.
作者 沈树红
机构地区 上海儿童医学中心血液肿瘤科
出处 《中国实用儿科杂志》 CSCD 北大核心 2016年第4期278-281,共4页 Chinese Journal of Practical Pediatrics
关键词 急性淋巴细胞白血病 血液肿瘤 基因 acute lymphoblastic leukemia hematology and oncology gene
分类号 R72 [医药卫生—儿科]
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参考文献16

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中国实用儿科杂志
2016年 第4期

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