TLIF治疗腰椎管狭窄并不稳在肥胖与非肥胖患者临床疗效比较

Comparison of the clinical efficacy between obesity and non-obesity with lumbar spinal stenosis and instability by transforaminal lumbar interbody fusion

目的探讨肥胖对开放及微创经椎间孔腰椎椎体间融合术(TLIF)治疗腰椎管狭窄并不稳临床疗效的影响。方法回顾性分析2011年1月至2013年1月于广西医科大学第四附属医院接受手术治疗的139例单节段腰椎管狭窄并失稳患者的临床资料,观察并比较不同手术组的围术期参数、临床疗效及术后影像学检查等各项指标。结果 34例肥胖患者及105例非肥胖患者在开放组及微创组中进行相关指标比较。其中肥胖患者围术期指标在开放组均大于非肥胖组,差异有统计学意义(P<0.01);在微创组中,肥胖组与非肥胖组术中出血量及切口长度比较差异有统计学意义(P<0.05),而手术时间比较无明显差异(P>0.05)。139例患者均获得随访,随访时间为6个月,无脱钉、断钉现象。所有患者在开放或微创手术后6个月随访视觉模拟(VAS)评分及疗效情况(ODI)评分均较术前有明显改善(P<0.01)。在开放和微创手术中,肥胖组与非肥胖组术后6个月ODI评分比较,差异有统计学意义(P<0.05);而VAS评分比较,差异无统计学意义(P>0.05)。结论肥胖可能是影响TLIF治疗的不利因素。

Objective To observe the clinic efficacy of open transforaminal lumbar interbody fusion（TLIF）compared with minimally invasive operation in treating lumbar spinal stenosis and instability among obese and non-obese patients.Methods A retrospective analysis was performed in these cases of mono-segmental lumbar spinal stenosis and instability between January 2011 and January 2013.Perioperative index,clinical efficacy,and imaging results were observed and compared between different groups.Results Thirty-four obese cases and 105non-obese cases were divided into two groups,including conventional posterior open TLIF and minimally invasive TLIF operation,to compare the results.Perioperative indexes of obese patients were more than non-obese patients undergone open TLIF operation way and there was significant difference（P〈0.01）;while by minimally invasiveTLIF operation way,comparing the results of the surgical blood loss and incision size between obese and non-obese group,there was significant difference（P〈0.05）.However,there was not significant difference in the operative time between two groups（P〉0.05）.No cases of slippage or breakage of implants were found among all these patients after 6months of follow up.Postoperative VAS and ODI among these four groups were better than before（P〈0.01）.Undergoing open postoperative VAS in obese group and in nonobese group,there was significant difference（P〈0.05）;undergoing minimally invasive postoperative ODI in obese group and in non-obese group,there was significant difference（P〈0.05）.But,undergoing open postoperative ODI in obese group and in nonobese group,there was not significant difference（P〉0.05）;undergoing minimally invasive postoperative VAS in obese group and in non-obese group,there was not significant difference（P〉0.05）.Conclusion Therefore,obese may be risk factor in treating lumbar spinal stenosis and instability.