结核感染T细胞斑点试验对儿童结核病的诊断价值

T-SPOT.TB Test Value in the Diagnosis of Childhood Tuberculosis

目的:探讨在儿童结核病诊断中应用结核感染T细胞斑点试验的价值。方法:2014年1月-2015年8月笔者所在医院共收治了28例结核病患儿,将其作为观察组,另选28例非结核病患儿作为对照组,对两组患儿分别实施结核感染T细胞斑点试验、PPD皮试、红细胞沉降率检测、结核抗体检测,评估诊断结果。结果:结核感染T细胞斑点试验诊断儿童结核病的敏感性为92.86%,特异性为96.43%;PPD皮试敏感性、特异性分别为82.14%、71.43%;红细胞沉降率检测敏感性、特异性分别为60.71%、25.00%;结核抗体检测敏感性、特异性分别为39.29%、89.29%。结论:在儿童结核病诊断中,结核感染T细胞斑点试验敏感性较强,诊断价值较高,值得临床应用。

Objective：To explore the application diagnosis of T-SPOT.TB testing value in childhood tuberculosis.Method：From January 2014 to August 2015,28 children with TB which were treated in our hospital were selected as the observation group,28 cases of non-tuberculosis（TB） were selected as control group,the children in two groups were taken,the T-SPOT.TB test,PPD skin test,blood sedimentation,tuberculosis antibody detection respectively and the diagnosis were evaluated.Result：The sensitivity of T-SPOT.TB test in the diagnosis of childhood tuberculosis was 92.86%,specificity was 96.43%.The sensitivity and specificity of PPD skin test were 82.14%,71.43% respectively.Blood sedimentation detection sensitivity,specificity were 60.71%,25.00% respectively.The sensitivity and specificity of tuberculosis antibody detection was 39.29%,89.29% respectively.Conclusion：T-SPOT.TB test is stronger sensitivity and higher diagnostic value in tuberculosis diagnosis in children,worthy of clinical application.