胚胎移植位置对体外受精临床结局的影响

Influence of embryo transfer location on IVF clinical outcome

目的探讨在腹部超声引导下定位胚胎移植对体外受精（IVF）-胚胎移植妊娠结局的影响。方法回顾性研究2014年1月至2015年1月在四川省人民医院生殖中心行IVF患者406例,按超声下移植胚胎距宫底距离占宫深比例的不同分为五组：A组（≤1/5）共58个周期、B组（〉1/5~2/5）共82个周期、C组（〉2/5~3/5）共104个周期、D组（〉3/5~4/5）共96个周期、E组（〉4/5）共66个周期。比较胚胎移植位置对IVF结局的影响。结果胚胎移植位置占宫深比例在大于1/5~4/5的B、C、D组的临床妊娠率（56.10%、56.73%、55.21%）明显高于A、E组（22.41%、21.21%）,差异均有统计学意义（P〈0.05）;而各组异位妊娠率、流产率比较,差异均无统计学意义（P〉0.05）。结论移植胚胎位置距离宫底的位置占宫深的比例在大于1/5~4/5时,会有更高的临床妊娠率。

Objective To investigate the influence of positioning embryo transfer on the in vitro fertilization（IVF）-embryo transfer（ET） pregnant outcome under the abdominal ultrasound guidance. Methods A total of 406 women undergoing IVF in the reproductive medicine center of our hospital from January 2014 to January 2015 were analyzed retrospectively. All 406 cas-es were divided into five groups according to different proportions of embryo transfer distance from the uterine fundus occupying the uterine depth：the group A（≤1/5） with 58 cycles,B（〉1/5-2/5） with 82 cycles,C（〉2/5-3/5） with 104 cycles,D（〉3/5-4/5）with 96 cycles and E（〉4/5） with 66 cycles. The influence of embryo transfer location on the IVF outcome was compared. Results In the proportion of embryo transfer location from the uterine fundus occupying the uterine depth 〉1/5~4/5,the pregnancy rates in the group B,C and D were 56.10%,56.73% and 55.21% respectively,which were significantly higher than 22.41% and 21.21%in the group A and E,the differences were statistically significant（P〈0.05）. But there were no statistically significant differences in the aspects of ectopic pregnancy rate and abortion rate among the five groups（P/,0.05）. Conclusion The proportion of embryo transfer location from the uterine fundus occupying the uterine depth/,1/5-4/5 has higher clinical pregnancy rate.