γ-氨基丁酸联合常规雾化吸入治疗对哮喘患者血清学指标和诱导痰指标的影响

Effect of γ-aminobutyric acid combined with conventional aerosol inhalation therapy on serum indicators and induced sputum indicators of patients with asthma

目的：分析γ-氨基丁酸联合常规雾化吸入治疗对哮喘患者血清学指标和诱导痰指标的影响。方法：选取在本院接受治疗的哮喘患者116例纳入研究,对治疗方案及化验结果进行回顾性分析后,所有入组患者被分为观察组（n=60）、对照组（n=56）。对比两组血清及诱导痰中病情相关因子及蛋白表达情况差异。结果：观察组治疗后血清PDGF-BB、SP、LTE4、CGRP水平低于对照组,TGFβ1水平高于对照组,差异具有统计学意义（P〈0.05）;观察组高于对照组,差异具有统计学意义（P〈0.05）;观察组治疗后诱导痰SCF、M-CSF、CKLF1、ICAM-1水平低于对照组,差异具有统计学意义（P〈0.05）;观察组治疗后诱导痰MCP-1、Gal-3、RAGE、HMGB1、SDF-1水平均低于对照组,差异具有统计学意义（P〈0.05）。结论：哮喘患者接受γ-氨基丁酸联合常规雾化吸入治疗,血清及诱导痰病情严重程度相关指标水平均得到优化,对于疾病治疗及预后转化等均有积极意义。

Objective：To analyze the effects ofγ-aminobutyric acid combining with conventional aerosol inhalation therapy on serum indicators and induced sputum indicators of patients with asthma.Methods：A total of 116 asthma patients receiving treatment in our hospital were included for the study.Data on treatment methods and laboratory results were retrospectively analyzed,and then all patients were divided into observation group（n=60）and control group（n=56）.Differences in illness-related factor and protein expression in serum and induced sputum were compared between two groups.Results：Serum PDGF-BB,SP,LTE4 and CGRP levels of observation group after treatment were lower than those of control group,and TGFβ1 level was higher than that of control group（P〈0.05）.SCF,M-CSF,CKLF1 and ICAM-1 levels in induced sputum of observation group after treatment were lower than those of control group（P〈0.05）;After treatment,MCP-1,Gal-3,RAGE,HMGB1 and SDF-1 levels in induced sputum of observation group were lower than those of control group（P〈0.05）.Conclusion：For patients with asthma,γ-aminobutyric acid combined with conventional aerosol inhalation therapy can improve the levels of disease severity-related indicators in serum and induced sputum,thus it is beneficial for treatment and prognosis of the disease.