放射性125I粒子置入联合TACE治疗对原发性肝癌患者血清标志物及肿瘤组织中凋亡分子的影响

Effect of 125I radioactive particle implantation combined with TACE treatment on serum markers apoptotic molecules in tumor tissue of patients with primary hepatocellular carcinoma

目的：分析放射性^125I粒子置入联合TACE治疗对原发性肝癌患者血清标志物及肿瘤组织中凋亡分子的影响。方法：选取在本院接受治疗的原发性肝癌患者纳入研究,随机分为观察组及对照组。对照组接受单纯TACE治疗,观察组接受放射性^125I粒子置入联合TACE治疗,对比两组血清标志物水平、肿瘤组织中凋亡相关基因的蛋白表达量差异。结果：观察组治疗后血清AFP、AFP-L3、GP73值均低于对照组（P〈0.05）;观察组治疗后血清GPC3、TGF-β1、DCP、AFU值较对照组相应指标值低（P〈0.05）;观察组接受治疗后的c-Met、端粒酶、FasL蛋白表达量低于对照组,Fas、Caspase-3蛋白表达量高于对照组（P〈0.05）;观察组接受治疗后的肝癌组织中p53、Bax蛋白表达量高于对照组,livin、Bcl-2蛋白表达量低于对照组（P〈0.05）。结论：原发性肝癌患者接受放射性^125I粒子置入联合TACE治疗,可以有效抑制肝癌细胞活性、促进肝癌细胞凋亡。

Objective：To analyze the effect of ^125I radioactive particle implantation combined with TACE treatment on serum markers apoptotic molecules in tumor tissue of patients with primary hepatocellular carcinoma.Methods：Patients with primary hepatocellular carcinoma treated in our hospital were included for study and randomly divided into observation group and control group.Control group received TACE treatment alone,observation group received ^125I radioactive particle implantation combined with TACE treatment,and then differences in serum marker levels and protein expression of apoptosis-related genes in tumor tissue were compared between two groups.Results：Serum AFP,AFP-L3 and GP73 values of observation group after treatment were lower than those of control group（P〈0.05）;serum GPC3,TGF-β1,DCP and AFU values of observation group after treatment were lower than corresponding indicator values of control group（P〈0.05）;protein expression levels of c-Met,telomerase and FasL of observation group after treatment were lower than those of control group,and protein expression levels of Fas and Caspase-3 were higher than those of control group（P〈0.05）;protein expression levels of p53 and Bax in liver cancer tissue of observation group after treatment were higher than those of control group,and protein expression levels of livin and Bcl-2 were lower than those of control group（P〈0.05）.Conclusion：^125I radioactive particle implantation combined with TACE treatment for patients with primary hepatocellular carcinoma can effectively inhibit liver cancer cell activity and promote liver cancer cell apoptosis.