托拉塞米注射液治疗慢性心力衰竭急性加重期的疗效分析

Clinical efficacy of analysis of torasemide injection for acute exacerbation of chronic heart failure

目的：观察托拉塞米注射液治疗慢性心力衰竭急性加重的临床疗效。方法：选取60例慢性心力衰竭急性加重期患者随机分为治疗组和对照组。在常规治疗的基础上,对照组应用呋塞米注射液40 mg/d,治疗组应用托拉塞米注射液40 mg/d,均连续使用3 d。观察两组临床症状、体征、心功能、尿量、BNP等的变化,并记录不良反应。结果：临床疗效比较,治疗组总有效率高于对照组,差异有显著统计学意义（χ^2=7.925,P=0.005）;治疗后尿量比较：治疗组24 h尿量、48 h总尿量、72 h总尿量均高于对照组,差异有统计学意义（P〈0.05）;治疗后的BNP水平,治疗组明显低于对照组,差异有显著统计学意义（P〈0.01）;治疗组平均CCU监护治疗天数低于对照组,差异有显著统计学意义（P〈0.01）。治疗组低钾血症发生率低于对照组,差异有统计学意义（P〈0.05）。结论：托拉塞米注射液治疗慢性心力衰竭急性加重期疗效确切,低钾血症发生率更低。

Objective To observe the clinical curative effect of torasemide injection for acute exacerbation of chronic heart failure. Method 60 cases of acute exacer- bation of chronic heart failure were randomly divided into treatment group and control group. Along with conventional treatment,the control group were treated with furosemide injection 40 mg / d,and the treatment group were treated with torasemide injection 40 mg / d,both continuous use 3 d. The two groups were observed changes in clinical symptoms,signs,heart function,urine volume,BNP; and the adverse reaction was recarded. Results Clinical effecacy comparison：the total effective rate of treatment group was higher than that of the control group,the difference was statistically significant（ χ~2= 7. 925,P = 0. 005）; comparison of urine volume after treatment： the treatment group 24 h urine volume,48 h total volume of urine,72 h total volume of urine were higher than those in the control group,the difference was statistically significant（ P〈0. 05）; after treatment,the BNP level of treatment group was significantly lower than that of the control group,the difference was statistically significant（ P〈0. 01）; the average number of days of CCU care treatment in treatment group was less than that in the control group,the difference was statistically significant（ P〈0. 01）. The incidence of hypokalemia in treatment group was lower than the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Torasemide injection for patients on acute exacerbation of chronic heart failure is effective,lower incidence of hypokalemia.