摘要
药物性肝损伤(DILI)已成为医生、科研人员、制药企业及药品管理部门所关注的热点问题,研究药物性肝损伤的影响因素对准确预测和预防药物性肝损伤的发生十分重要,但目前对药物性肝损伤的了解仍然有限。实际上,药物性肝损伤的发生风险和临床转归是由药物和机体多个方面的相互作用来决定。笔者系统性的讨论影响药物性肝损伤发生发展的药物特性和机体因素,为进一步深入了解药物性肝损伤提供支持。
Drug-induced liver injury（ DILI） is a hot topic for clinicians,academia,drug companies and regulators. It is essential to understand risk factors of idiosyncratic DILI in order to accurately predict and prevent this problem. However,the role of factors on the pathogenesis of DILI is poorly understood. Indeed,both drug properties and host factors are likely interact at multiple levels to determine individual risks and clinical outcome of DILI. In this review,cross-disciplinary view over drug characteristics associated with hepatotoxicity is provided,and various host factors influencing individuals＇ DILI risks at updating the current knowledge to stimulate future investigation are discussed.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2016年第8期607-611,共5页
Chinese Pharmaceutical Journal
基金
中国博士后科学基金面上资助项目(2014M561160)
关键词
药物性肝损伤
肝毒性
特异质反应
药物特性
机体因素
drug-induced liver injury（DILI）
hepatotoxicity
idiosyncratic reaction
drug characteristics
host factors
