芪参胶囊对合并糖代谢异常冠心病患者血液流变学的影响

Impact of qishen capsule on blood rheology level among patients with coronary heart disease combined with abnormal glucose metabolism

目的:探讨芪参胶囊对合并糖代谢异常冠心病患者血液流变学的影响。方法:选择在"IL-33和e NOS基因标签SNPs与冠心病发生的关联研究"中经冠脉造影明确诊断为冠心病同时伴有糖代谢异常的68例患者,其中32例患者在冠心病二级预防治疗和有效控制血糖基础上加用芪参胶囊治疗作为治疗组,36例患者仅给予冠心病二级预防和有效控制血糖作为对照组,对2组患者起始治疗前和治疗6周后血液流变学指标进行统计学分析比较。结果:2组患者血液流变学各项指标比较,差异均有统计学意义(P<0.05)。结论:芪参胶囊能降低合并糖代谢异常的冠心病患者血黏度,增强预防治疗的疗效,可用作提高冠心病二级预防效果的药物。

Objective： To investigate impact of qishen capsule on blood rheology level among patients with established coronary heart disease（ CHD） combined with abnormal glucose metabolism. Methods： In the study of ＂ Correlation between gene tag SNPs of IL-33 and e NOS and risk of CHD＂,66 patients with established CHD combined with abnormal glucose metabolism were divided into 2 groups： a treatment group（ n = 32） and a control group（ n = 34）. The control group was treated with grade II prevention and glucose-lowering therapy,while the treatment group,on the basis of the control group,was added with combined qishen capsule treatment. Blood rheology changes before and after the treatment were comparatively analyzed. Results： Blood rheology level of the treatment group was significantly lower than that of the control group after treatment. The difference was significant（ P 0. 05）. Conclusion： Blood rheology level of patients with established CHD combined with abnormal glucose metabolism can be lowered when treated with qishen capsule.