摘要
动脉粥样硬化斑块破裂可导致严重的临床事件(如心肌梗死和脑卒中)。巨噬细胞是动脉粥样硬化斑块内最主要的炎性细胞,它可根据不同的微环境分化成不同表型的巨噬细胞。其中,M1型巨噬细胞主要位于斑块不稳定区,M2型巨噬细胞主要位于斑块的稳定区。随着动脉粥样硬化斑块的进展,斑块内积聚的巨噬细胞逐渐增多,而斑块内不断蓄积的巨噬细胞主要依赖于局部巨噬细胞的增殖,而不是血中单核细胞的分化。
The rupture of atherosclerotic plaque can lead to severe consequences,such as myocardial infraction and stroke. Macrophages are the predominant inflammatory cells within the plaques,which are very versatile and can polarize different phenotypes depending on the local microenvironment. M1 macrophages are exclusively found in unstable plaques and M2 macrophages being higher in stable plaques. The incremental accumulation of macrophages corresponded with plaque progression,are mainly derived from local proliferation rather than from the influx of blood-borne monocytes.
出处
《医学综述》
2016年第8期1468-1471,共4页
Medical Recapitulate
基金
国家自然科学基金(81460052)
关键词
动脉粥样硬化斑块
巨噬细胞
分布
蓄积
Atherosclerotic plaques
Macrophage
Distribution
Accumulation
