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硫酸镁联合丹参注射液在妊娠期高血压疾病中的疗效 被引量:18

The Curative Effect of Magnesium Sulfate Combined with Salvia Miltiorrhiza Injection in the Treatment of Patients with Gestational Hypertension
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摘要 目的探究硫酸镁联合丹参注射液在妊娠期高血压中的疗效。方法选取2011年5月至2014年7月琼海市人民医院收治的妊娠期高血压患者124例,采用随机数字表法分为对照组和观察组,各62例。对照组给予硫酸镁治疗,25%硫酸镁注射液30 m L与5%葡萄糖液500 m L稀释后静脉滴注,每日1次。观察组给予硫酸镁联合丹参注射液治疗,20 m L丹参注射液与5%葡萄糖250 m L稀释后静脉滴注,每日1次。比较两组患者平均动脉压(MAP)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、24 h尿蛋白等指标。结果治疗后,观察组MAP、24 h尿蛋白、FBI低于对照组[(14.0±1.3)k Pa比(15.3±1.5)k Pa,(672±79)mg比(751±87)mg、(3.16±0.55)g/L比(4.26±0.53)g/L],PT、APTT高于对照组[(12.9±1.2)s比(11.4±1.1)s,(29.7±4.2)s比(24.4±3.6)s](P<0.01);观察组总不良妊娠结局发生率显著低于对照组[24.2%(15/62)比46.8%(29/62)],差异有统计学意义(P<0.05)。结论硫酸镁联合丹参注射液治疗妊娠期高血压效果优良,值得临床推广。 Objective To explore the curative effect of magnesium sulfate combined with salvia miltiorrhiza injection in the treatment of patients with gestational hypertension. Methods Total of 124 patients with gestational hypertension treated in the department of obstetrics and gynecology in Qionghai City People's Hospital from May 2011 to Jul. 2014 were included in the study,and divided into control group and observation group according to random number table method,62 cases each. The control group was given magnesium sulfate treatment,30 m L of 25% magnesium sulfate injection,diluted with 500 m L of 5% glucose solution for intravenous infusion,once a day. The observation group was given magnesium sulfate with salvia miltiorrhiza injection therapy,20 m L salvia injection diluted with 250 m L of 5% glucose for intravenous infusion once daily. The mean arterial pressure( MAP),prothrombin time( PT),activated partial thromboplastin time( APTT),protein fiber( FIB),and 24 h urinary protein of the two groups were compared. Results After treatment,the MAP,24 h urinary protein,FBI of the observation group were lower than the control group[( 14. 0 ± 1. 3) k Pa vs( 15. 3 ± 1. 5) k Pa,( 672 ± 79) mg vs( 751 ± 87) mg,( 3. 16 ± 0. 55) g/L vs( 4. 26 ± 0. 53) g/L],PT,APTT were higher than the control group [( 12. 9 ± 1. 2) s vs( 11. 4 ± 1. 1) s,( 29. 7 ± 4. 2) s vs( 24. 4 ± 3. 6) s]( P〈 0. 01). The total incidence of adverse pregnancy outcomes of the observation group was significantly lower than the control group[24. 2%( 15 /62) vs 46. 8%( 29 /62) ],the difference was statistically significant( P〈 0. 05). Conclusion Magnesium sulfate combined with salvia miltiorrhiza injection has a good effect in the treatment of gestational hypertension,thus is worth clinical promotion.
出处 《医学综述》 2016年第8期1603-1606,共4页 Medical Recapitulate
关键词 妊娠期高血压 硫酸镁 丹参注射液 平均动脉压 24 h尿蛋白 Gestational hypertension Magnesium sulfate Salvia miltiorrhiza injection Mean arterial pressure 24 h urine protein
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