人参复方多糖对老年晚期非小细胞肺癌患者免疫功能和生活质量的影响

Effect of Compound Ginseng Polysaccharide on Immune Function and Quality of Life in Elder Patients with Advanced Non-small Cell Lung Cancer

目的分析人参复方多糖对老年晚期非小细胞肺癌患者免疫功能和生活质量的影响。方法选取2012年1月至2014年1月孝感市中心医院108例确诊为晚期非小细胞肺癌的老年患者,采用随机数字表法将108例患者分为观察组(60例)和对照组(48例)。观察组接受复方人参多糖治疗,每日静脉滴注18 mg,30 d为1个疗程,连续使用2个疗程;对照组未接受复方人参多糖治疗。两组患者其他放疗、化疗方案相同,分别测定两组患者治疗前后的T细胞亚群、血清免疫球蛋白(Ig)和生活质量(QOL评分)。结果观察组总缓解率为56.7%(34/60);对照组总缓解率为33.3%(16/48)。两组总缓解率差异无统计学意义(P>0.05)。观察组CD3和CD4显著高于对照组[(65±10)%比(54±10)%,(41±8)%比(35±9)%](P<0.05)。治疗后观察组Ig A、Ig G、Ig M均显著高于对照组[(1.39±0.10)g/L比(1.30±0.12)g/L、(11.2±2.1)g/L比(10.2±2.0)g/L、(1.72±0.17)g/L比(1.42±0.17)g/L](P<0.05)。观察组QOL评分治疗1个月较治疗前升高,治疗3个月较治疗前降低;对照组QOL评分治疗1个月较治疗前升高,治疗3个月较治疗前变化不大[观察组:(40±12)分,(42±11)分,(35±8)分;对照组:(40±13)分,(45±15)分,(40±12)分],差异有统计学意义(P<0.05)。结论人参复方多糖能改善老年晚期非小细胞肺癌患者免疫功能和生活质量。

Objective To analyze the effect of compound ginseng polysaccharides on immune function and quality of life in elder patients with non-small cell lung cancer（ NSCLC）. Methods Total of 108 elder patients with advanced NSCLC from Xiaogan Central Hospital during Jan. 2012 and Jan. 2014 were included in the study,and were divided into observation group（ receiving treatment with compound ginseng polysaccharides,every day intravenously 18 mg,30 d as a course of treatment,continuously for two courses,n = 60） and control group（ without treatment of compound ginseng polysaccharide,n = 48） according to random number table method. The two groups of patients received same radiotherapy,chemotherapy regimens. T cell subgroup,serum immunoglobulin（ Ig） and quality of life（ QOL score） of the two groups before and after treatment were detected. Results The overall response rate of the observation group was 56. 7%（ 34 /60）,of the control group was 33. 3%（ 16 /48）,the difference was not statistically significant（ P〉0. 05）. CD3 and CD4of the observation group were significantly higher than the control group [（ 65 ± 10） % vs（ 54 ± 10） %,（ 41 ± 8） % vs（ 35 ± 9） % ],the differences were statistically significant（ P〈0. 05）. Ig A,Ig G and Ig M of the observation group after treatment were significantly higher than the control group [（ 1. 39 ± 0. 10） g / L vs（ 1. 30 ± 0. 12） g/L,（ 11. 2 ± 2. 1） g/L vs（ 10. 2 ± 2. 0） g/L,（ 1. 72 ± 0. 17） g/L vs（ 1. 42 ± 0. 17） g/L]（ P〈0. 05）. The QOL scores of the observation group 1 month after treatment increased than before treatment,3 months after treatment reduced than before; QOL of the control group 1 month after treatment increased than before treatment,and fell back to before treatment level 3 months after treatment[observation group：（ 40 ± 12） scores,（ 42 ± 11） scores,（ 35 ± 8） scores; control group：（ 40 ± 13） scores,（ 45 ± 15）scores,（ 40 ± 12） scores],the differences were statistically significant（ P〈0. 05）. Conclusion Compound ginseng polysaccharide can improve the immune function and quality of life in elder patients with advanced NSCLC.