艰难梭菌毒素的研究进展

Research progresss of Clostridium diffi cile toxin

艰难梭菌是引起抗菌药物相关性腹泻和伪膜性结肠炎的主要致病菌,致病性主要是由毒素介导,所产生的毒素因导致肠道正常菌群失调,肠道黏膜的损伤而引起一系列与感染相关的临床症状。且近年来,艰难梭菌感染率逐年上升,尤其是高毒力菌株的出现,病死率也不断上升,已引起全世界的关注。因此,对艰难梭菌毒素相关研究进行综述,将为防治艰难梭菌感染提供依据。

Clostridium difficile is a main pathogenic bacterium implicated in antibiotic-associated diarrhea and pseudomembranous colitis by production of toxin which cause intestinal floral alteration, intestinal mucosa injury and a series of infection in clinic.Recently, hypervirulent strains have emerged rapidly and caused much more clostridium difficile infection and fatality in all over the world. This paper presents a review on Clostridium diJficile toxin and could provide basis for Clostridium difficile infection control.