美罗培南与乌司他丁在重症感染患者治疗中的效果分析

Application of meropenem and ulinastatin in the emergency treatment of severe infections

目的探讨美罗培南与乌司他丁在急诊重症感染患者治疗中的应用效果,为临床治疗提供参考依据。方法选取2013年6月-2015年6月于医院接受治疗的急诊重症感染住院患者100例为研究对象,根据随机数字表法分成对照组和试验组,每组各50例,对照组采用美罗培南进行,并采用呼吸辅助、营养调节等措施;试验组在对照组的基础上同时给予乌司他丁进行治疗,比较两组患者临床指标,数据采用SPPS 18.0软件进行统计分析。结果治疗5d后,两组患者血清前降钙素原浓度、APACHEⅡ评分、肿瘤坏死因子-α(TNF-α)及高敏C-反应蛋白(hs-CRP)浓度均降低,且试验组降低程度明显大于对照组;对照组30d存活率明显低于试验组(P<0.05)。结论急诊重症感染患者在使用美罗培南抗感染、运用呼吸辅助治疗、营养调节等有效措施的基础上,加用乌司他丁治疗,能有效改善其临床体征,减轻感染对机体的损伤,达到理想的重症感染治疗效果。

OBJECTIVE To investigate the effectiveness of meropenem and ulinastatin applying in the emergency treatment of severe infections,in order to provide evidence for clinical treatment.METHODS A total of 100 hospitalized patients with severe infections in emergency room of our hospital from Jun.2013 to Jun.2015 were selected.Based on the random number table,they were divided into control and experimental groups with 50 cases in each group.The control group was treated with antibiotics meropenem for anti-infective therapy,and was also given respiratory assistance,nutrition regulation and other measures.While the experimental group was given UTI treatment on the basis of the control group.Clinical indicators of the two groups were compared and the results were statistically analyzed with software SPPS 18.0.RESULTS After 5days treatment,serum procalcitonin concentrations,APACHE Ⅱ score,TNF-αhs-CRP concentration of patients in the two groups decreased,and the results of the experimental group was significantly higher than that of the control group.The 30days＇ survival rate of control group was significantly lower than that of the experimental group（P〈0.05）.CONCLUSION On the basis of meropenem′s resistance to infection,respiratory adjuvant therapy and nutrition regulation,the application of UTI emergency treatment for severe infections,can effectively improve the clinical signs of severe infection,reduce the damage to the body of infection,and achieve the desired therapeutic effect of severe infection.