莫西沙星序贯疗法治疗老年下呼吸道感染患者的疗效及对白细胞介素表达的影响

Effect of sequential therapy of moxifloxacin on treatment of elderly patients with lower respiratory tract infections and influence on expression of interleukins

目的观察莫西沙星序贯疗法治疗老年下呼吸道感染患者的疗效,研究其对白细胞介素表达的影响,以期为老年下呼吸道感染治疗提供有效的方案。方法将2014年2月-2015年8月医院内科收诊的150例下呼吸道感染老年患者随机分为对照组和观察组,各75例,在常规治疗的基础上,观察组接受莫西沙星序贯疗法治疗,对照组患者则给予头孢他啶治疗,比较两组患者的临床疗效及治疗前后血清白细胞介素(IL)水平。结果观察组患者总有效率为97.33%、对照组为84.00%;治疗7d后,观察组血清IL-6、IL-8、IL-10水平分别为(13.5±7.3)(18.3±6.3)(12.3±7.1)pg/ml,显著低于对照组,两组比较差异均有统计学意义(P<0.05)。结论莫西沙星序贯疗法治疗老年下呼吸道感染的疗效优于头孢他啶,能缩短症状消失时间,促进患者尽快康复。

OBJECTIVE To observe the effect of sequential therapy of moxifloxacin on treatment of elderly patients with lower respiratory tract infections and study the influence on the expression of interleukins so as to provide guidance for effective treatment of the elderly patients with lower respiratory tract infections.METHODS A total of 150 elderly patients with lower respiratory tract infections who were treated in the hospital from Feb 2014 to Aug 2015 were enrolled in the study and randomly divided into the control group and the observation group,with75 cases in each.The observation group was treated with sequential therapy of moxifloxacin,while the control group was given ceftazidime.The clinical therapeutic effects and levels of serum interleukins（IL）were observed and compared between the two groups of patients.RESULTS The total effective rate was 97.33%in the observation group,84.00% in the control group.The levels of serum IL-6,IL-8,and IL-10 of the observation group were respectively（13.5±7.3）pg/ml,（18.3±6.3）pg/ml,and（12.3±7.1）pg/ml after the treatment for 7days,significantly lower than those of the control group,and there was significant difference between the two groups（P〈0.05）.CONCLUSIONThe effect of the sequential therapy of moxifloxacin is better than that of ceftazidime on treatment of the elderly patients with lower respiratory tract infections,it can shorten the time of disappearance of symptoms and promote the rapid recovery of patients.