胆道感染患者病原菌分布与临床特征分析

Distribution of pathogenic bacteria and clinical characteristics in patients with biliary tract infections

目的分析胆道感染的病原菌分布和临床特征,为制定临床预防控制方案提供参考依据。方法选取2013年1月-2014年1月胆道感染的患者150例作为研究对象,对其胆汁中的病原菌分布和临床特征进行观察和分析。结果共有113例患者的胆汁培养结果呈阳性,阳性率为75.3%,共分离出131株病原菌,以革兰阴性菌为主,共88占67.2%;logistic多元回归分析结果显示,胆道手术史、合并胆结石、合并胰腺癌为发生胆道感染的独立危险因素(P<0.05)。结论胆道感染患者的病原菌分布和临床特征均具有一定的特性,临床医师应给予高度关注,采用有效的预防和治疗措施,达到提高治疗效果和改善患者预后的目的。

OBJECTIVE To analyze the distribution of pathogenic bacteria and clinical characteristics in biliary tract infections,and to provide objective evidence for development of clinical prevention and control program.METHODS Totally 150 patients had bile culture from Jan.2013 to Jan.2014 were selected as the research subjects.The distribution of pathogenic bacteria in bile and the clinical characteristics of the patients were observed and analyzed.RESULTS A total of 113 cases of patients＇ bile culture were positive,the positive rate was 75.3%.A total of 131 strains of pathogens were isolated,among them,gram negative bacterial dominated,accounting for67.2%.According to logistic multivariate regression analysis,biliary operation history,complication of gallstone,complication of pancreatic cancer were independent risk factors of biliary tract infections（P〈0.05）.CONCLUSIONThe distribution of pathogenic bacteria and clinical characteristics in patients with biliary tract infections has certain characteristics,which the clinicians should pay high attention to and employ effective prevention and treatment measures to improve the therapeutic effects and prognosis of patients.