系统性红斑狼疮患者合并侵袭性真菌病的临床危险因素分析

Analysis the clinical risk factors of systemic lupus erythematosus patients with invasive fungal disease

目的探讨系统性红斑狼疮(SLE)患者合并侵袭性真菌病(IFD)的临床危险因素。方法收集2009年1月至2013年12月在昆明医科大学第二附属医院皮肤性病/风湿免疫科病房住院诊断为SLE的患者,对合并IFD及无任何系统感染的SLE患者,进行单因素分析和多因素Logistic回归分析,寻找SLE合并IFD的危险因素。结果共收集了803例SLE患者,其中合并IFD的共计27例,同时期未发生系统感染的27例SLE患者作为对照组,单因素分析发现有15个危险因素,多因素分析仅发现3个独立危险因素。结论对于SLE合并IFD的危险因素分析,发现大多数危险因素是相互关联的,可能是一系列因素的共同作用导致了SLE患者容易并发IFD,而疑似感染症状、SLEDAI评分≧8分、CRP≥0.8mg/dl是SLE合并IFD的独立危险因素。

Objective To study the clinical risk factors of systemic lupus erythematosus （SLE） patients complicated with invasive fungal disease （IFD） Methods We collected the clinical datas of SLE patients from January, 2009 to December , 2013 in the Second Affiliated Hospital of Kunming Medical U- niversity dermatology / rheumatology ward, using the single factor analysis method and multi factor Logistic regression analysis method to analyse risk factors, in SLE patients complicated with IFD and without any system infection. Results We collected 27 cases SLE patients with IFD and 27cases without any sys- tem infection patients in all 803 cases of SLE. The single factor analysis found 15 risk factors, and the multi factor analysis showed 3 independent risk fac- tors. Conclusion Analysing the risk factors of the SLE with IFD, we found that the most risk factors are related to each other,a series of risk factors led to the IFD in SLE patients. And. suspected infection symptoms,the score of SLEDA138, CRP 30. 8mg/dl are independent risk factors.