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Dectin-1 mRNA在寻常型银屑病患者皮损中的表达

Expressions of dectin-1 mRNA in lesions from patients with psoriasis vulgaris
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摘要 目的检测寻常型银屑病患者皮损组织中dectin-1 mRNA的表达,探讨dectin-1在银屑病发病中的可能机制。方法采用实时荧光定量聚合酶链反应(RFQ-PCR)检测15例寻常型银屑病患者皮损组织及15例正常皮肤组织中dectin-1 mRNA的表达。结果寻常型银屑病患者皮损中dectin-1 mRNA的表达为(0.01020±0.00686),较正常皮肤组织(0.00232±0.00073)明显升高,差异有统计学意义(P<0.05)。结论 Dectin-1 mRNA表达水平在寻常型银屑病患者皮损中明显升高,其可能在寻常型银屑病患者皮肤局部免疫反应中起作用。 Objective To detect the expression levels of dectin-1 mRNA in lesions from patients with psoriasis vulgaris. Methods Real-time fluores- cence quantitative PCR（RFQ-PCR） was applied to detect the expressions of dectin- 1 mRNA in 15 lesions of patients and 15 normal skins. Results The mean value of dectin-1 mRNA expression levels in psoriatic lesions was 0.01020±0.00686, it＇s significantly higher than that in normal skins （0.00232＋0. 00073 ） （p〈0.05）. Conclusion The expression levels of dectin-1 mRNA were significantly increased in the lesions of patients with psoriasis vulgaris, it may play a role in the local immune response in this disease.
作者 王倩 刘伟 陈杰 张丽霞 段西凌
机构地区 四川省医学科学院四川省人民医院皮肤性病研究所 四川省医学科学院四川省人民医院中心实验室
出处 《皮肤病与性病》 2016年第2期83-85,共3页 Dermatology and Venereology
基金 四川省卫生厅科研课题(编号130168)
关键词 银屑病 寻常型 DECTIN-1 C型凝集素 Psoriasis Vulgaris Dectin- 1 C-type Lectin
分类号 R751.03 [医药卫生—皮肤病学与性病学] R758.63 [医药卫生—皮肤病学与性病学]
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参考文献13

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二级参考文献25

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皮肤病与性病
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