非酒精性脂肪性肝病治疗进展

Advances in the treatment of non-alcoholic fatty liver disease

非酒精性脂肪性肝病是一种与胰岛素抵抗及遗传易感性密切相关的代谢应激性疾病。随着人们生活水平的不断提高,患病率呈不断上升趋势。非酒精性脂肪性肝病不仅可导致转氨酶持续异常、失代偿期肝硬化、肝功能衰竭等严重肝病,也与心血管疾病、2型糖尿病、代谢综合征的发生存在密切联系,严重威胁着人们的健康。因此,非酒精性脂肪性肝病的治疗越来越受到重视,其治疗原则包括:①去除病因,治疗原发基础病;②基础治疗:生活方式干预、饮食调整及运动治疗等基本措施:③针对不同的病理学特征,因人而异予辅助药物治疗;④终末期行肝移植治疗。本文将重点对生活方式干预、减肥手术及药物治疗的进展状况进行综述。

Non-alcoholic fatty liver disease is a metabolic stress disorder which is closely related to insulin resistance and genetic susceptibility. As the living standards continue improving, the prevalence has been rising. Non-alcoholic fatty liver disease can not only cause seriously abnormal liver transaminases, decompensated cirrhosis, liver failure and so on, but also is associated with cardiovascular disease, type 2 diabetes and metabolic syndrome, which is a serious threat to the health of people. Therefore, the treatment of non-alcoholic fatty liver disease causes more and more attention, and the treatment principles include： Removal of the cause and to treat the primary underlying diseases; Basic measures of treatment： lifestyle intervention, dietary modification, exercise therapy and so on; To give a supplementary drug therapy varying from person to person according to different pathologic features; For end-stage liver disease, liver transplantation is recommend. This article will focus on lifestyle interventions, weight loss surgery and drug treatment progress.