摘要
对羟基苯甲醛经甲氧基甲基醚保护后,发生Wittig缩合得到4-甲氧甲氧基苯乙烯,再与3,5-二甲氧基苯甲酰氯依次经钌/炭催化的Heck交叉偶联和酸水解的脱甲氧基甲基醚保护基反应,得到紫檀茋,总收率约78%。
Pterostilbene was synthesized from p-hydroxybenzaldehyde via protection into methoxymethyl ether and Wittig condensation to obtain 4-(methoxymethoxy)styrene, which was subjected to Heck cross-coupling reaction with 3,5-dimethoxybenzoyl chloride in the presence of Ru/C catalysis, and deprotection of methoxymethyl ether with an overall yield of about 78%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2016年第4期388-390,共3页
Chinese Journal of Pharmaceuticals
基金
浙江省教育厅一般科研项目(Y201534541)