不同毒品成瘾者中医证素与肝功指标间关联性研究

CORRELATION OF TRADITIONAL CHINESE MEDICINE SYNDROME FACTORS OF DIFFERENT DRUG ADDICTS WITH LIVER FUNCTION INDEX

目的:探讨不同毒品成瘾者的中医证素与肝功指标间的关联性。方法:对54例自愿参加调查的福州市则徐戒毒所的自愿戒毒者采集四诊信息,根据其成瘾毒品种类分为三组:海洛因组、冰毒组、氯胺酮组。应用证素辨证方法提取三组的中医证素,并且检测肝功相关指标,采用二元逻辑回归分析其相关性。结果:(1)海洛因组与冰毒组的病位证素与肝功指标具有相关性的指标多为ALT、AST。(2)病性证素与肝功指标相关的证素为热,但相关理化指标在海洛因与冰毒组均为危险因子,在氯胺酮组为保护因子。结论:吸食不同种类的毒品成瘾者肝功指标可能与中医证素相关,肝功指标可做为证素辨证的参考指标之一。

Objective：To explore the correlation of traditional Chinese medicine（ TCM）pathological factors with liver function among different drug addicts.Methods：The diagnostic information based on four TCM diagnostic methods was collected from 54 cases voluntarily participated in Zexu Rehabilitation of the Voluntary Detoxification in Fuzhou,which were divided into three groups：heroin group,methamphetamine group,and ketamine group,according to the type of drug addiction. The TCM syndrome factor differentiation method was used to extract pathogenic factors of three groups,to detect liver function indicators,and to analyze the relationship with binary logistic regression.Results：（ 1） ALT and AST were correlated with index of hepatic function and disease syndrome factor in heroin and methamphetamine groups.（ 2） Heat had correlation with disease syndrome and hepatic function index.Physical and chemical indicators were risk factors in the heroin and methamphetamine groups,but were protective factors in ketamine group.Conclusion：Liver function indexes are related to the TCM syndrome factor in different kinds of drug addicts,which can be used as reference indicators of syndrome factor differentiation.