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双歧杆菌四联活菌治疗非酒精性脂肪肝的疗效观察 被引量:10

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摘要 目的观察双歧杆菌四联活菌治疗非酒精性脂肪肝(NAFLD)的疗效。方法选取120例NAFLD患者采用随机数字表法分为对照组(常规护肝药物)60例和观察组(双歧杆菌四联活菌)60例,比较两组患者治疗前后肝功能、血脂、治疗总有效率的变化。结果两组患者治疗后丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰胺转移酶(GGT)、总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)水平均低于治疗前,高密度脂蛋白胆固醇(HDL-C)水平高于治疗前,差异有统计学意义(P<0.05)。观察组患者治疗后ALT、AST、GGT、TG、TC、LDL-C水平均显著低于对照组,HDL-C水平高于对照组,差异具有统计学意义(P<0.05)。患者治疗总有效率观察组为88.3%,对照组为70.0%,差异有统计学意义(P<0.05)。结论应用双歧杆菌四联活菌片不仅能有效改善NAFLD患者的临床症状及体征,还可改善肝功能指标,调节脂质代谢,具有临床推广价值。
出处 《广东医学》 CAS 北大核心 2016年第8期1221-1222,共2页 Guangdong Medical Journal
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  • 1Latea L, Negrea S, Bolboaca S. Primary non -alcoholic fatty liver disease in hypertensive patients [ J]. Australas Med J, 2013, 6 (6) : 325.
  • 2Compare D, Coccoli P, Rocco A, et al. Gut - liver axis: the im- pact of gut microbiota on non alcoholic fatty liver disease[J], Nutr Metab Cardiovasc Dis, 2012, 22(6) : 471 -476.
  • 3Aron - Wisnewsky J, Gaborit B, Dutour A, et al. Gut microbiota and non -alcoholic fatty liver disease: new insights[ J ]. Clin Mi- crobial Infect, 2013, 19(4) : 338 -348.
  • 4Kasturiratne A, Akiyama K, Niriela MA, et al. Association of ge- netic variants with non - alcoholic fatty liver disease in an urban Sri Lankan community[J]. Liver Int, 2014, 19(10) : 12624.
  • 5Szabo G, Bala S, Petrasek J, et al. Gut - liver axis and sensing microbes[Jl. Dig Dis, 2010, 28(6): 737 -744.
  • 6Tremaroli V, Bckhed F. Functional interactions between the gut microbiota and host metabolism[ J]. Nature, 2012, 489 (7415): 242 - 249.
  • 7Iacono A, Raso GM, Canani RB, et al. Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and bio- chemical mechanisms [ J ]. Nutr Biochem, 2011, 22 ( 8 ) : 699 - 711.
  • 8Spruss A, Kanuri G, Stahl C, et al. Metformin protects against the development of fructose - induced steatosis in mice : role of the in- testinal barrier function [ J ]. Lab Invest, 2012, 92 ( 7 ) : 1020 - 1032.
  • 9Esposito E, Iacono A, Bianco G, et al. Probiotics reduce the in- flammatory response induced by a high - fat diet in the liver of young rats[J]. J Nutr, 2009, 139(5) : 905 -911.
  • 10Guo Z, Liu XM, Zhang QX, et al. Influence of consumption of probiotics on the plasma lipid profile : a meta - analysis of random- ised controlled trials [ J]. Nutr Metab Cardiovase Dis, 2011, 21 (11) : 844 -850.

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