二萜成分7-hydroxyl-hedychenone的酰化、烷基化及抗肿瘤活性研究

Acylation and Alkylation of a Diterpene,7-Hydroxyl-Hedychenone and Antitumor Researches of the Products

目的以二萜成分7-hydroxyl-hedychenone制备具有体外抗肿瘤活性的衍生物。方法对7-hydroxylhedychenone进行酰化及烷基化,制备4个衍生物,并对其中3个进行体外抗肿瘤活性测试。结果共制备4个二萜衍生物,其中1个衍生物对2种肿瘤细胞具有体外抗肿瘤活性。结论以二萜为原料进行酰化和烷基化,制备具有抗肿瘤活性成分是可行的。

Objective A diterpeneoid,7-hydroxyl-hedychenone was utilized to synthesis bioactive derivatives. Methods 7-hydroxyl-hedychenone was acylated or alkylated,as a result,four derivatives were obtained,three of which were subjected to in vitro antitumor bioassays. Results Four diterpene derivatives were obtained,one derivative showed antitumor activity against two cancer cell lines. Conclusion It is feasible to obtain derivatives with antitumor activity from natural diterpenoids.