氟伐他汀对老年心力衰竭患者心功能、血浆NT-ProBNP及炎性因子水平的影响

Effect of fluvastatin on the cardiac function, plasma NT-Pro BNP and inflammatory factor Level in elderly patients with heart failure

目的探讨氟伐他汀治疗老年心力衰竭的疗效及对心功能、血浆N-末端脑钠肽（NT-Pro BNP）及炎性因子水平的影响。方法选取2012年1月~2015年4月我院收治的120例老年心力衰竭患者,随机将所选患者分为研究组和对照组,每组60例,对照组采用心力衰竭常规药物治疗,研究组在对照组的基础上联用氟伐他汀治疗,综合比较两组患者治疗总有效率、治疗前后NT-Pro BNP、肿瘤坏死因子（TNF-α）、白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）及不良反应情况的差异。结果研究组患者治疗总有效率明显高于对照组的81.7%（P〈0.05）;治疗后研究组NT-Pro BNP、TNF-α、IL-6及hs-CRP水平均低于对照组（P〈0.05）;两组患者均无不良反应发生,患者耐受性好。结论氟伐他汀治疗老年心力衰竭患者效果确切,可明显改善患者心功能,抑制血小板聚集,显著降低血浆NT-Pro BNP及炎性因子水平,值得临床推广使用。

Objective To explore the effect of fluvastatin on the cardiac function, plasma N-terminal probrain natriuretic peptide（plasma NT-Pro BNP） and inflammatory factor level in elderly patients with heart failure. Methods 120 elderly patients with heart failure who were admitted to our hospital from January 2012 to April 2015 were selected and they were randomly divided into the research group and the control group, with 60 in each. The control group was treated with conventional drugs for heart failure while the research group was treated with fluvastatin at the basis of the control group. The total effective rate, NT-Pro BNP, tumor necrosis factor（TNF-α）, interleukin-6（IL-6）, ultra-sensitivity C-reactive protein（hs-CRP） before and after treatment and adverse reactions of two groups were compared. Results The total effective rate of the research group was higher than that of the control group 81.7%（P〈 0.05）. After treatment, the NT-Pro BNP, TNF-α, IL-6 and hs-CRP levels of the research group were all lower than those of the control group（P〈 0.05）. Patients in two groups all had no adverse reaction and they were all well tolerated. Conclusion Fluvastatin in treating elderly patients with heart failure has accurate effect. It can significantly improve cardiac functions, inhibit platelet aggregation and decrease plasma NT-Pro BNP and inflammatory factors levels, worthy of clinical promotion and application.