胰岛素泵及利拉鲁肽序贯疗法对新发糖尿病患者的疗效观察

Clinical observation of Insulin pump and the liraglutide sequential therapy for new onset diabetic patients

目的分析研究胰岛素泵及利拉鲁肽序贯疗法对新发糖尿病患者的疗效。方法选取2014年1月~2015年1月于我科住院的初诊的2型糖尿病患者,所有患者均给予胰岛素泵进行强化治疗。采用随机数字表将患者随机分为口服降糖药治疗组、利拉鲁肽治疗组,每组60例。测量患者的BMI、血糖、血脂、血压、胰岛素、C肽及Hcy。结果两组患者TC、TG、LDL-C、HDL-C、Hb A1C及Hcy的值治疗前后均有明显改善（P〈0.05）,且观察组的改善程度明显高于对照组（P〈0.05）。观察组患者的BMI、SBP和DBP治疗后明显低于治疗前（P〈0.05）,对照组的此三值虽均有下降,但差异无统计学意义（P〉0.05）。两组患者FPG、1h FPG、2h FPG、FCP、CP1h、CP2h、HOMA-IR及HOMA-β的值治疗前后均有明显改善（P〈0.05）,且观察组的改善程度明显高于对照组（P〈0.05）。两组患者的FINS水平治疗后较治疗前均有升高,但差异无统计学意义（P〉0.05）。结论胰岛素泵联合利拉鲁肽可显著降低患者的体重,改善血糖、血脂及血压等,使糖尿病症状缓解。

Objective To analyze and study the effect of the insulin pump and the liraglutide sequential therapy on new-onset diabetes. Methods Patients who were newly diagnosed with type 2 diabetes were selected from January 2014 to January 2015 in our hospital and all patients were given intensive treatment with insulin pump. According to random number table,patients were randomly divided into oral treatment group with xylene guanidine and the treatment group with liraglutide. Each group involved 60 people. BMI, blood glucose, blood lipids, blood pressure, insulin, C-peptide and Hcy of patients were measured. Results After treatment, the TC, TG, LDL-C, HDL-C, Hb A1 C and Hcy values of two group patients were significantly improved（P〈 0.05）, and the improvement of the observation group was significantly higher than that of control group（P0.05）. The BMI, SBP and DBP of observation group patients were significantly lower than before treatment（P〈 0.05）.While the three values of the control group were decreased,there were not statistical significance（P〈 0.05）. After treatment, FPG, 1h FPG, 2h FPG, FCP, CP1 h, CP2 h, HOMA-IR and HOMA-β of two group patients were significantly improved（P〈 0.05）, and the improvement of the observation group was significantly higher than that of the control group（P〈 0.05）. After treatment, the FINS levels of two group patients were increased, but there were not statistical significance（P〈 0.05）. ConclusionInsulin pump combined with liraglutide can improve weight, blood sugar, blood fat and blood pressure of patients and so on,and relieve diabetes symptoms of patients.