老药新用:氯胺酮的快速抗抑郁作用及其机制研究

New use of old drug: introduction of the antidepressant effects of ketamine and the underlying mechanisms

氯胺酮是一种非选择性N-甲基-D-天门冬氨酸(NMDA)受体拮抗剂,常作为全身麻醉药用于临床。近年来研究发现,氯胺酮具有快速、有效、持久的抗抑郁作用,该作用可能与抑制性中间神经元、兴奋性神经递激质、AMPA受体及突触后多种信号通路所介导的突触可塑性增强有关。文中简单介绍氯胺酮抗抑郁作用及其机制。

Ketamine, a non-selective N-methyl-D-aspartate （NMDA） receptor antagonist, is widely used as a general anesthetic in clinical practice. Recent studies have shown that ketamine can produce rapid, effective, and long-lasting antidepressant effects, and the strength of synaptic plasticity induced by inhibitory interneurons, excitatory transmitters, AMPA receptors, and postsynaptic signal pathways may be involved in this procedure. The antidepressant effects of ketamine and the underlying mechanisms are concisely introduced in this paper.