外用糠酸莫米松联合果酸治疗斑块型银屑病疗效观察

Effectiveness observation of topical treatment for psoriasis by mometasone furoate combine with alpha hydroxyl acids

目的:探讨外用糠酸莫米松联合果酸(ARAs)治疗斑块型银屑病的临床疗效。方法:治疗组双上肢皮损进行果酸治疗,1次/周,同时外用糠酸莫米松乳膏,2次/d,身体其余皮损外用糠酸莫米松乳膏;对照组所有皮损仅外用糠酸莫米松乳膏治疗,用法同治疗组,每周复查,直至4周治疗结束。结果:治疗第2周,治疗组和对照组的有效率分别为50.0%、30.0%,疗效比较差异无统计学意义(P>0.05);治疗第4周,治疗组和对照组的有效率分别87.5%、65.0%,差异有统计学意义(P<0.05)。结论:外用糠酸莫米松乳膏联合果酸治疗斑块型银屑病疗效显著,果酸可作为斑块型银屑病有效的辅助治疗药物。

Objective To investigate the clinical effect of the treatment with plaque psoriasis by topical alpha hydroxyl acids（ARAs）. Methods Treatment group： the skin lesions of the double upper limb treated by ARAs, 1 times /w, and topical cream Mometasone furoate, 2 times /d, the rest of lesions on body with Mometasone furoate cream. The control group were treated only with Mometasone furoate cream, the usage with treatment group. Two groups＇ treatment were until the end of 4w. Results The effective rates of the treatment group and the control group were 50% and 30% after 2 weeks, efficacy comparison was not statistically significant（P〈0.05）. And after 4weeks they were 87.5% and 65%, the difference was statistically significant（P〈0.05）. Conclusion Topical ARAs combined with cream mometasone furoate in the treatment with plaque psoriasis is effective, ARAs peeling can be used as an auxiliary treatment with plaque psoriasis effectively.