丙酮酸激酶M2在膀胱尿路上皮癌中的表达研究及临床意义

Expression and Significance of Pyruvate Kinase M2 in Bladder Urothelial Carcinoma

目的:探讨丙酮酸激酶M2(PKM2)在膀胱尿路上皮癌中的表达及其意义。方法:应用免疫组化SP法,分别检测50例膀胱尿路上皮细胞癌组织及15例正常膀胱组织中PKM2的表达,并结合临床资料进行分析。结果:PKM2在膀胱尿路上皮癌组织及正常膀胱组织中的阳性表达率分别为94.0%(47/50)和13.3%(1/15),比较差异有统计学意义(P<0.05)。随着膀胱尿路上皮癌病理分级及临床分期的增高,PKM2的表达增高,差异有统计学意义(P<0.05)。结论:PKM2在膀胱尿路上皮癌组织表达明显高于非癌组织,表明其在膀胱尿路上皮癌的发生发展中起重要作用,与膀胱尿路上皮癌的分期、转移有关。

Objective：To study the expression and significance of PKM2 in bladder urothelial carcinoma. Method：The expression of PKM2 was detected by immunohistochemistry in tissue sections from 50 cases of bladder urothelial carcinoma and 15 cases of normal bladder mucosa,and their correlation with clinical data features were analyzed.Result：The PKM2 expression rate in bladder urothelial carcinoma and normal bladder tissues were 94.0% and 13.3%,the difference was statistically significant（P〈0.05）.With the increase of pathological grade and clinical stage in bladder urothelial carcinoma,the expression of PKM2 was increased,the difference was statistically significant（P〈0.05）. Conclusion：The expression of PKM2 was higher in the bladder urothelial carcinoma than those in the noncancerous bladder tissue,which indicates that it may play an important role during the development of bladder urothelial carcinoma.And relationship to bladder urothelial carcinoma pathological grade,clinical stage and metastasis.