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芳香烃受体对心脏结构与功能的影响 被引量：1

The Influence of Aryl Hydrocarbon Receptor on Cardiac Structure and Function
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摘要 芳香经受体(aryl hydrocarbon receptor,Ah R)是存在于细胞胞质内的一种配体激活型转录因子,属于碱性螺旋-环-螺旋(basic helix-loop-helix,b HLH)超家族中Per-Arnt-Sim同源域(PerArnt-Sim homology domain,PAS)蛋白亚型。芳香烃受体与相应配体结合并被激活,并移位到细胞核内,与芳香烃受体核转运蛋白形成异二聚体复合物,此异二聚体可结合于相应的DNA序列,引发下游目的基因的转录及表达,产生一系列生物学效应。本文将对芳香烃受体对心脏结构与功能的影响作一综述。 The aryl hydrocarbon receptor（Ah R） is an evolutionarily old transcription factor belonging to the Per-ARNT-Sim-basic helix-loop-helix protein family.Ligand binding causes AHR to translocate to the nucleus,shed the chaperone proteins,and bind with aryl hydrocarbon receptor nuclear translocator（ARNT）.The AHR-ARNT heterodimer binds to dioxin response elements in the promoter region of downstream target genes and directly upregulates their expression.This article will define the mechanisms of Ah R responsible for the lifelong cardiovascular malformations.
作者 方瀚 黄石安
机构地区 广东医学院 广东医学院附属医院
出处 《中国医学创新》 CAS 2016年第11期140-144,共5页 Medical Innovation of China
关键词 芳香经受体 心血管系统 多环芳烃 Aryl hydrocarbon receptor Cardiovascular system Polycyclic aromatic hydrocarbons
分类号 R54 [医药卫生—心血管疾病]
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  • 1Mezrich J D, Fechner J H, Zhang X J, et al.An interaction between kynurenine and the Aryl hydrocarbon receptor can generate regulatory T cells[J].Journal of Immunology, 2010, 185 ( 6 ) : 3190-3198.
  • 2Ohtake F, Baba A, Takada I, et al.Dioxin receptor is a ligand- dependent E3 ubiquitin ligase[J].Nature, 2007, 446 ( 7135 ) : 562-566.
  • 3Lees M J, Whitelaw M L.Muhiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt[J]. Molecular and Cellular Biology, 1999, 19 ( 8 ) : 5811-5822.
  • 4Petrulis J R, Kusnadi A, Ramadoss P, et al.The hsp90 Co- chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity[J].The Journal of Biological Chemistry, 2003, 278 (4) : 2677-2685.
  • 5Pongratz I, Mason G G, Poellinger L.Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor.Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity[J].The Journal of Biological Chemistry, 1992, 267 ( 19 ): 13 728-13 734.
  • 6MeGnire J, Whitelaw M L, Pongratz I, et al.A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix- loop-helix dioxin receptor[J].Moleular and Cellular Biology, 1994, 14 (4) : 2438-2446.
  • 7Mahepe E, Sehmidt J V, Baunoeh D, et al.Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT[J].Nature, 1997, 386 ( 6623 ) :403 -407.
  • 8Puga A, Ma C, Marlowe J L.The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways[J].Biochem Pharmacol, 2009, 77 (4) : 713-722.
  • 9Tran C, Richmond O, Aaron L, et al.Inhibition of constitutive aryl hydrocarbon receptor ( AhR ) signaling attenuates androgen independent signaling and growth in ( C4-2 ) prostate cancer cells[J].Biochemical Pharmacology, 2013, 85 ( 6 ) : 753-762.
  • 10Chang J T, Chang H, Chen P H, et al.Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas[J].Clinical Cancer Research, 2007, 13 ( 1 ) : 38-45.

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中国医学创新
2016年 第11期

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