TNF-α、TGF-β及IL-10在慢性阻塞性肺疾病患者中的表达及临床意义

Expression and clinic value of serum TNF-α,TGF-β and IL-10 in patients with chronic obstructive pulmonary disease

目的观察肿瘤坏死因子-α（TNF-α）、转化生长因子-β（TGF-β）及白细胞介素-10（IL-10）在慢性阻塞性肺疾病（COPD）患者中的表达及其与病情的关系。方法检测2015年1月1日-12月31日我院收住的112例慢性阻塞性肺疾病急性加重（AECOPD）患者血清TNF-α、TGF-β及IL-10水平,并将其与COPD缓解期组及健康对照组比较。观察不同肺功能水平分级AECOPD患者上述炎症因子水平的差异。对AECOPD患者进行CAT评分,比较不同CAT评分组上述炎症因子的差异。结果急性加重期组患者血清TNF-α、TGF-β显著性高于缓解期及健康对照组,而IL-10显著性低于缓解期及健康对照组（P〈0.05）。缓解期TNF-α、TGF-β及IL-10水平与健康对照组比较,差异有统计学意义（P〈0.05）。不同肺功能水平患者TGF-β水平比较,差异有统计学意义（P〈0.05）。不同CAT评分组TNF-α、IL-10水平比较,差异有统计学意义（P〈0.05）。结论 TNF-α、TGF-β的升高及IL-10的降低参与了COPD的发生和发展。可能TNF-α主要与气道炎症的急性加重有关,TGF-β主要与气道重塑有关。

Objective To observe the relationship between the expression of TNF-α,TGF-β and IL-10 in COPD patients and the state of an illness. Methods The level of serum TNF-α, TGF-β and IL-10 of 112 AECOPD patients from January 1 to December 31 2015 were tested and were compared with COPD in the period of remission stage and health control group.The difference of above inflammatory factors level in AECOPD patients with different level of lung function classification were observed.CAT score of AECOPD patients were conducted and the differences between the CAT groups above inflammation factors were compared. Results The serum TNF-α and TGF-β in AECOPD patients were obvious higher than the patients in the period of remission stage and health control group,but IL-10 obvious lower than in the period of remission stage and health control group（P〈0.05）.These inflammatory factors in the period of remission stage also had obvious difference compared with health control group（P〈0.05）.The TGF-β had obvious difference among different lung function patients（P〈0.05）.The TNF-α and TGF-β had obvious between CAT score groups（P〈0.05）. Conclusion The increases of TNF-α and TGF-β and the decreases of IL-10 participate in the occurrence and development of COPD.TNF-α may mainly be related to cute exacerbation of airway inflammation and TGF-β may mainly be related to airway remodeling.