枸地氯雷他定联合富马酸酮替芬治疗慢性荨麻疹的效果观察

Effect observation of desloratadine citrate disodium combined with ketotifen fumarate in the treatment of chronic urticaria

目的探讨枸地氯雷他定联合富马酸酮替芬治疗慢性荨麻疹的临床效果。方法选取本院2014年1-12月收治的76例慢性荨麻疹患者作为研究对象,随机分对照组和观察组,各38例。对照组给予枸地氯雷他定治疗,观察组在对照组的基础上给予富马酸酮替芬治疗,比较两组的临床治疗效果。结果观察组的总有效率为84.2%,显著高于对照组的60.5%,差异有统计学意义（P〈0.05）。观察组的复发率显著低于对照组,差异有统计学意义（P〈0.05）。观察组治疗后的生活质量总评分显著低于对照组治疗后,差异有统计学意义（P〈0.05）。结论枸地氯雷他定联合富马酸酮替芬治疗慢性荨麻疹效果显著,能够降低患者复发率。

Objective To explore the clinical effect of desloratadine citrate disodium combined with ketotifen fumarate in the treatment of chronic urticaria. Methods 76 cases of chronic urticaria from January 2014 to December in our hospital were selected and randomly divided into the control group and the observation group,38 patients in each group.The control group was treated with desloratadine citrate disodium,the observation group was treated with ketotifen fumarate on the basis of the control group.The clinical treatment effect in the two groups was compared. Results The total effective rate of the observation group was 84.2%,which was higher than 65.0% of the control group,with significant difference（P〈0.05）.The recurrence rate of the observation group was higher than that of the control group,with significant difference（P〈0.05）.The total score of life quality after treatment in the observation group was lower than that in the control group after treatment,with significant difference（P〈0.05）. Conclusion Desloratadine citrate disodium combined with ketotifen fumarate in the treatment of chronic urticaria is significant,which can reduce the recurrence rate of patients.