替米沙坦联合氨氯地平与氨氯地平单药治疗原发性高血压病的疗效及安全性比较

Comparison of curative effect and safety between telmisartan combined with amlodipine and single amlodipine in the treatment of primary hypertension

目的探讨替米沙坦联合氨氯地平与氨氯地平单药治疗原发性高血压病的疗效及安全性。方法 80例原发性高血压病患者,随机分为试验组与对照组,各40例。对照组采取氨氯地平治疗,试验组采用替米沙坦联合氨氯地平,比较两组日间平均收缩压(d SBP)、舒张压(d DBP),夜间平均收缩压(n SBP)、舒张压(n DBP)以及安全性。结果治疗后试验组各指标均优于对照组(P<0.05)。结论采取替米沙坦联合氨氯地平治疗原发性高血压病,可以有效降低患者的平均血压,并且两药合用副作用少,值得在临床推广。

Objective To investigate curative effect and safety of telmisartan combined with amlodipine and single amlodipine in the treatment of primary hypertension. Methods A total of 80 patients with primary hypertension were randomly divided into experimental group and control group, with 40 cases in each group. The control group received amlodipine for treatment, and the experimental group received telmisartan combined with amlodipine. Comparison was made on day mean systolic blood pressure（d SBP）, day mean diastolic blood pressure（d DBP）, night mean systolic blood pressure（n SBP）, night mean diastolic blood pressure（n DBP） and safety between the two groups. Results The experimental group had all better indexes than the control group after treatment（P0.05）. Conclusion Combination of telmisartan and amlodipine can effectively reduce mean blood pressure in treating primary hypertension, along with few side effects. It is worth clinical promotion.