180例喹诺酮类药品的不良反应临床分析

Clinical analysis on 180 cases of quinolone drugs on adverse drug reactions

目的分析喹诺酮类药品不良反应(ADR)的发生特点和一般规律。方法通过药物不良反应监测网随机选取武汉地区医院2014年喹诺酮类药品使用时发生的不良反应180例,从ADR涉及的药品种类、数量与给药途径及发生时间等进行统计分析。结果 180例喹诺酮类药品不良反应的临床表现以胃肠道反应(35.55%)和中枢反应(37.78%)为多数。结论喹诺酮类药品临床上应规范合理使用,要掌握给药途径、适应证、用药禁忌证及患者过敏史,以提高用药的安全性。

Objective To investigate the occurrence characteristics and general rule of quinolone adverse drugs reactions. Methods Selected randomly 180 cases of adverse reactions of fluoroquinolone drugs occurred in 2014 in Wuhan by Adverse Drug Reactions Monitoring Network and analyzed the drug variety,quantity,administration route,occurrence time of adverse drugs reactions and its rational use systematically.Results The most common clinical appearances of 180 adverse drugs reactions cases are gastrointestinal reactions and nervous system reactions,35. 55 % and 37. 78% each. Conclusion Use quinolones rationally in clinical medicine and master administration route,its indication and contraindication disinfection coupled with the patient ＇s allergies to improve medication safety.