正常妊娠妇女、妊娠期高血压及妊娠期糖尿病患者脂类、载脂蛋白、血浆蛋白代谢变化的探讨

Discussion on lipids,apolipoproteins,plasma protein metabolic changes in normal pregnant women,gestational hypertension and gestational diabetes patients

目的探讨正常妊娠妇女、妊娠期高血压及妊娠期糖尿病患者三类研究对象血脂代谢特点,了解血脂代谢紊乱与妊娠期高血压、妊娠期糖尿病等疾病的关系。方法选择2012年11月至2015年11月于收治的正常妊娠妇女、妊娠期高血压及妊娠期糖尿病患者各500例,分别检测血清中总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)、白蛋白(ALB)、球蛋白(GLB)并进行比较。结果妊娠期高血压组及妊娠期糖尿病组的TC、TG、LDL及Apo-B水平明显高于正常妊娠妇女组,差异具有统计学意义(P<0.05);妊娠期高血压组、妊娠期糖尿病组的ALB、GLB、HDL及Apo-A1水平明显低于正常孕妇组,组间差异均有统计学意义(P<0.05)。结论妊娠期高血压及妊娠期糖尿病患者可能伴有血脂、血糖代谢的紊乱,临床应加强孕期及围生期监测。

Objective To discuss the lipids,apolipoproteins,plasma protein metabolic changes in normal pregnant women,gestational hypertension and gestational diabetes patients,to study the relationship between dyslipidemia and gestational hypertension,gestational diabetes and other diseases. Methods Selelcted 500 cases normal pregnant women,500 cases gestational hypertension and 500 cases gestational diabetes patients from November 2012 to November 2015. Detected serum total cholesterol（ CHOL）,triglycerides（ TRIG）,high density lipoprotein（ HDL-C）,low density lipoprotein（ LDL-C）,apolipoprotein A1（ Apo-A1）,apolipoprotein B（ Apo-B）,albumin（ ALB）,globulin（ GLB） and compared the results. Results Gestational hypertension and gestational diabetes group was significantly higher than normal pregnant women group in TC,TG,LDL and Apo-B,the difference was statistically significant（ P〈0. 05）; gestational hypertension group,gestational diabetes group was significantly lower than normal pregnant women group in ALB,GLB,HDL and Apo-A1,there were significant differences between the two groups（ P〈0. 05）. Conclusion Gestational hypertension and gestational diabetes may be associated with lipid and glucose metabolism disorders,we should be strengthened and perinatal monitoring on clinical pregnancy.